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Dengue virus-specific memory t cell responses in human volunteers receiving a live attenuated dengue virus type 2 candidate vaccine

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dc.contributor.authorTararaj Dharakulen_US
dc.contributor.authorIchiro Kuraneen_US
dc.contributor.authorNatth Bhamarapravatien_US
dc.contributor.authorSutee Vaughnen_US
dc.contributor.authorDavid W. Vaughnen_US
dc.contributor.authorCharles H. Hokeen_US
dc.contributor.authorFrancis A. Ennisen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherUniversity of Massachusetts Medical Schoolen_US
dc.contributor.otherWalter Reed Army Institute of Researchen_US
dc.contributor.otherArmed Forces Research Institute of Medical Sciences, Thailanden_US
dc.date.accessioned2018-02-27T04:29:29Z
dc.date.available2018-02-27T04:29:29Z
dc.date.issued1994-01-01en_US
dc.description.abstractA live attenuated dengue virus type 2 candidate vaccine (16681-PDK53) was evaluated in a phase I trial in 10 nonimmune adult volunteers. The dengue virus-specific memory T cell responses were analyzed as part of this study. Dengue virus-specific T cell proliferative responses were observed in all subjects after stimulating their peripheral blood mononuclear cells with live viruses or noninfectious viral antigens. The highest proliferative response was against dengue virus type 2, although cross-reactivity with other flaviviruses was detected to a lesser degree in some subjects. Dengue virus type 2-specific CD4 + and CD8 + cytotoxic T lymphocytes were generated in all vaccinees. This study investigated whether the candidate vaccine was efficacious in inducing dengue virus-specific CD4 + and CD8 + T cell memory after a single immunization in nonimmune recipients. © 1994 by The University of Chicago.en_US
dc.identifier.citationJournal of Infectious Diseases. Vol.170, No.1 (1994), 27-33en_US
dc.identifier.doi10.1093/infdis/170.1.27en_US
dc.identifier.issn15376613en_US
dc.identifier.issn00221899en_US
dc.identifier.other2-s2.0-0028364079en_US
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/20.500.14594/9843
dc.rightsMahidol Universityen_US
dc.rights.holderSCOPUSen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0028364079&origin=inwarden_US
dc.subjectMedicineen_US
dc.titleDengue virus-specific memory t cell responses in human volunteers receiving a live attenuated dengue virus type 2 candidate vaccineen_US
dc.typeArticleen_US
dspace.entity.typePublication
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0028364079&origin=inwarden_US

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