Publication:
Metal-free regioselective direct thiolation of 2-pyridones

Issued Date

2019-01-01

Resource Type

Article

ISSN

14770520

DOI

10.1039/c9ob01061k

Other identifier(s)

2-s2.0-85068380881

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Organic and Biomolecular Chemistry. Vol.17, No.26 (2019), 6432-6440

Suggested Citation

Kunita Phakdeeyothin, Sirilata Yotphan Metal-free regioselective direct thiolation of 2-pyridones. Organic and Biomolecular Chemistry. Vol.17, No.26 (2019), 6432-6440. doi:10.1039/c9ob01061k Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/50303

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Title

Metal-free regioselective direct thiolation of 2-pyridones

Author(s)

Kunita Phakdeeyothin
 Sirilata Yotphan

Other Contributor(s)

Mahidol University

Abstract

© The Royal Society of Chemistry. A highly regioselective metal-free direct C-H thiolation of 2-pyridones with disulfides or thiols has been developed. A combination of persulfate and a commercially available halide source such as LiCl, NCS or I2 enables the successful direct incorporation of a sulfide moiety into the 5-position of pyridone under mild conditions, providing a useful and convenient approach for the preparation of a diverse array of 5-thio-substituted pyridones in moderate to excellent yields.

Keyword(s)

Biochemistry, Genetics and Molecular Biology
 Chemistry

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/50303

Collections

Scopus 2019