Publication: Immunopathogenesis of Dengue Virus-Induced Redundant Cell Death: Apoptosis and Pyroptosis
Issued Date
2017-01-01
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ISSN
15578976
08828245
08828245
Other identifier(s)
2-s2.0-85009909977
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Mahidol University
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SCOPUS
Bibliographic Citation
Viral Immunology. Vol.30, No.1 (2017), 13-19
Suggested Citation
San Suwanmanee, Natthanej Luplertlop Immunopathogenesis of Dengue Virus-Induced Redundant Cell Death: Apoptosis and Pyroptosis. Viral Immunology. Vol.30, No.1 (2017), 13-19. doi:10.1089/vim.2016.0092 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/42017
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Title
Immunopathogenesis of Dengue Virus-Induced Redundant Cell Death: Apoptosis and Pyroptosis
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Abstract
Copyright © 2017, Mary Ann Liebert, Inc. 2017. Dengue virus infection is a self-limited condition, which is of particular importance in tropical and subtropical regions and for which no specific treatment or effective vaccine is available. There are several hypotheses explaining dengue pathogenesis. These usually refer to host immune responses, including antibody-dependent enhancement, cytokine expression, and dengue virus particles including NS1 protein, which lead to cell death by both apoptosis and pyroptosis. A clear understanding of the pathogenesis should facilitate the development of vaccines and therapies. This review focuses on the immunopathogenesis in relation to clinical manifestations and patterns of cell death, focusing on the pathogenesis of severe dengue.