Publication: Proteomic identification of a direct role for cyclin D1 in DNA damage repair
Issued Date
2012-09-01
Resource Type
ISSN
15387445
00085472
00085472
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2-s2.0-84865710342
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Mahidol University
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SCOPUS
Bibliographic Citation
Cancer Research. Vol.72, No.17 (2012), 4289-4293
Suggested Citation
Siwanon Jirawatnotai, Yiduo Hu, David M. Livingston, Piotr Sicinski Proteomic identification of a direct role for cyclin D1 in DNA damage repair. Cancer Research. Vol.72, No.17 (2012), 4289-4293. doi:10.1158/0008-5472.CAN-11-3549 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/13625
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Title
Proteomic identification of a direct role for cyclin D1 in DNA damage repair
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Abstract
The human CCND1 gene, which encodes the cell-cycle protein cyclin D1, is one of the most frequently amplified genes in human cancers. Cyclin D1 activates the cyclin-dependent kinases CDK4 and CDK6 and drives cell proliferation. Beyond the cell-cycle role, the full repertoire of cyclin D1 functions in cancer cells is still unclear. Emerging evidence indicates that cyclin D1 may play a role in DNA damage response. In this review, we discuss observations linking cyclin D1 to DNA damage repair and summarize our recent findings, which show a cyclin D1 function in homologous recombination-mediated DNA repair. ©2012 AACR.