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Proteomic identification of a direct role for cyclin D1 in DNA damage repair

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dc.contributor.authorSiwanon Jirawatnotaien_US
dc.contributor.authorYiduo Huen_US
dc.contributor.authorDavid M. Livingstonen_US
dc.contributor.authorPiotr Sicinskien_US
dc.contributor.otherHarvard Medical Schoolen_US
dc.contributor.otherMahidol Universityen_US
dc.date.accessioned2018-06-11T04:34:14Z
dc.date.available2018-06-11T04:34:14Z
dc.date.issued2012-09-01en_US
dc.description.abstractThe human CCND1 gene, which encodes the cell-cycle protein cyclin D1, is one of the most frequently amplified genes in human cancers. Cyclin D1 activates the cyclin-dependent kinases CDK4 and CDK6 and drives cell proliferation. Beyond the cell-cycle role, the full repertoire of cyclin D1 functions in cancer cells is still unclear. Emerging evidence indicates that cyclin D1 may play a role in DNA damage response. In this review, we discuss observations linking cyclin D1 to DNA damage repair and summarize our recent findings, which show a cyclin D1 function in homologous recombination-mediated DNA repair. ©2012 AACR.en_US
dc.identifier.citationCancer Research. Vol.72, No.17 (2012), 4289-4293en_US
dc.identifier.doi10.1158/0008-5472.CAN-11-3549en_US
dc.identifier.issn15387445en_US
dc.identifier.issn00085472en_US
dc.identifier.other2-s2.0-84865710342en_US
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/20.500.14594/13625
dc.rightsMahidol Universityen_US
dc.rights.holderSCOPUSen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84865710342&origin=inwarden_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.subjectMedicineen_US
dc.titleProteomic identification of a direct role for cyclin D1 in DNA damage repairen_US
dc.typeReviewen_US
dspace.entity.typePublication
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84865710342&origin=inwarden_US

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