Publication:
Isolation and Structure Elucidation of a Novel Antimalarial Macrocyclic Polylactone, Menisporopsin A, from the Fungus Menisporopsis theobromae

1

Issued Date

2004-04-01

Resource Type

Article

ISSN

01633864

DOI

10.1021/np0304870

Other identifier(s)

2-s2.0-2042517594

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Journal of Natural Products. Vol.67, No.4 (2004), 689-692

Suggested Citation

Maneekarn Chinworrungsee, Prasat Kittakoop, Masahiko Isaka, Pacharee Maithip, Sumalee Supothina, Yodhathai Thebtaranonth Isolation and Structure Elucidation of a Novel Antimalarial Macrocyclic Polylactone, Menisporopsin A, from the Fungus Menisporopsis theobromae. Journal of Natural Products. Vol.67, No.4 (2004), 689-692. doi:10.1021/np0304870 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/21208

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Title

Isolation and Structure Elucidation of a Novel Antimalarial Macrocyclic Polylactone, Menisporopsin A, from the Fungus Menisporopsis theobromae

Author(s)

Maneekarn Chinworrungsee
 Prasat Kittakoop
 Masahiko Isaka
 Pacharee Maithip
 Sumalee Supothina
 Yodhathai Thebtaranonth

Other Contributor(s)

Mahidol University
 Thailand National Center for Genetic Engineering and Biotechnology

Abstract

An antimalarial macrocyclic polylactone, menisporopsin A (1), was isolated from a cell extract of the seed fungus Menisporopsis theobromae. The structure of 1 was elucidated on the basis of spectroscopic analysis and chemical transformations, with the absolute configuration established by application of the modified Mosher method and by using chiral HPLC. Menisporopsin A (1) possesses an unprecedented residue, 2,4-dihydroxy-6-(2,4-dihydroxy-n-pentyl)benzoic acid. This compound exhibited antimalarial activity, with an IC50 value of 4.0 μg mL -1, and antimycobacterial activity (MIC value of 50 μg mL -1).

Keyword(s)

Biochemistry, Genetics and Molecular Biology
 Chemistry
 Medicine
 Pharmacology, Toxicology and Pharmaceutics

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URI

https://repository.li.mahidol.ac.th/handle/123456789/21208

Collections

Scopus 2001-2005