Publication: Isolation and Structure Elucidation of a Novel Antimalarial Macrocyclic Polylactone, Menisporopsin A, from the Fungus Menisporopsis theobromae
| dc.contributor.author | Maneekarn Chinworrungsee | en_US |
| dc.contributor.author | Prasat Kittakoop | en_US |
| dc.contributor.author | Masahiko Isaka | en_US |
| dc.contributor.author | Pacharee Maithip | en_US |
| dc.contributor.author | Sumalee Supothina | en_US |
| dc.contributor.author | Yodhathai Thebtaranonth | en_US |
| dc.contributor.other | Mahidol University | en_US |
| dc.contributor.other | Thailand National Center for Genetic Engineering and Biotechnology | en_US |
| dc.date.accessioned | 2018-07-24T03:38:04Z | |
| dc.date.available | 2018-07-24T03:38:04Z | |
| dc.date.issued | 2004-04-01 | en_US |
| dc.description.abstract | An antimalarial macrocyclic polylactone, menisporopsin A (1), was isolated from a cell extract of the seed fungus Menisporopsis theobromae. The structure of 1 was elucidated on the basis of spectroscopic analysis and chemical transformations, with the absolute configuration established by application of the modified Mosher method and by using chiral HPLC. Menisporopsin A (1) possesses an unprecedented residue, 2,4-dihydroxy-6-(2,4-dihydroxy-n-pentyl)benzoic acid. This compound exhibited antimalarial activity, with an IC50 value of 4.0 μg mL -1, and antimycobacterial activity (MIC value of 50 μg mL -1). | en_US |
| dc.identifier.citation | Journal of Natural Products. Vol.67, No.4 (2004), 689-692 | en_US |
| dc.identifier.doi | 10.1021/np0304870 | en_US |
| dc.identifier.issn | 01633864 | en_US |
| dc.identifier.other | 2-s2.0-2042517594 | en_US |
| dc.identifier.uri | https://repository.li.mahidol.ac.th/handle/20.500.14594/21208 | |
| dc.rights | Mahidol University | en_US |
| dc.rights.holder | SCOPUS | en_US |
| dc.source.uri | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=2042517594&origin=inward | en_US |
| dc.subject | Biochemistry, Genetics and Molecular Biology | en_US |
| dc.subject | Chemistry | en_US |
| dc.subject | Medicine | en_US |
| dc.subject | Pharmacology, Toxicology and Pharmaceutics | en_US |
| dc.title | Isolation and Structure Elucidation of a Novel Antimalarial Macrocyclic Polylactone, Menisporopsin A, from the Fungus Menisporopsis theobromae | en_US |
| dc.type | Article | en_US |
| dspace.entity.type | Publication | |
| mu.datasource.scopus | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=2042517594&origin=inward | en_US |