Publication:
Aigialomycins A-E, new resorcylic macrolides from the marine mangrove fungus Aigialus parvus

Issued Date

2002-03-08

Resource Type

Article

ISSN

00223263

DOI

10.1021/jo010930g

Other identifier(s)

2-s2.0-0037040681

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Journal of Organic Chemistry. Vol.67, No.5 (2002), 1561-1566

Suggested Citation

Masahiko Isaka, Chotika Suyarnsestakorn, Morakot Tanticharoen, Palangpon Kongsaeree, Yodhathai Thebtaranonth Aigialomycins A-E, new resorcylic macrolides from the marine mangrove fungus Aigialus parvus. Journal of Organic Chemistry. Vol.67, No.5 (2002), 1561-1566. doi:10.1021/jo010930g Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/20136

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Title

Aigialomycins A-E, new resorcylic macrolides from the marine mangrove fungus Aigialus parvus

Author(s)

Masahiko Isaka
 Chotika Suyarnsestakorn
 Morakot Tanticharoen
 Palangpon Kongsaeree
 Yodhathai Thebtaranonth

Other Contributor(s)

Thailand National Center for Genetic Engineering and Biotechnology
 Mahidol University

Abstract

Aigialomycins A-E (2-6), new 14-membered resorcylic macrolides, were isolated together with a known hypothemycin (1) from the mangrove fungus, Aigialus parvus BCC 5311. Structures of these compounds, including absolute configuration, were elucidated by spectroscopic methods, chemical conversions, and X-ray crystallographic analysis. Hypothemycin and aigialomycin D (5) exhibited in vitro antimalarial activity with IC50 values of 2.2 and 6.6 μg/mL, respectively, while other analogues were inactive. Cytotoxicities of these compounds were also evaluated.

Keyword(s)

Chemistry

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/20136

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Scopus 2001-2005