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Aigialomycins A-E, new resorcylic macrolides from the marine mangrove fungus Aigialus parvus

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dc.contributor.authorMasahiko Isakaen_US
dc.contributor.authorChotika Suyarnsestakornen_US
dc.contributor.authorMorakot Tanticharoenen_US
dc.contributor.authorPalangpon Kongsaereeen_US
dc.contributor.authorYodhathai Thebtaranonthen_US
dc.contributor.otherThailand National Center for Genetic Engineering and Biotechnologyen_US
dc.contributor.otherMahidol Universityen_US
dc.date.accessioned2018-07-24T02:58:58Z
dc.date.available2018-07-24T02:58:58Z
dc.date.issued2002-03-08en_US
dc.description.abstractAigialomycins A-E (2-6), new 14-membered resorcylic macrolides, were isolated together with a known hypothemycin (1) from the mangrove fungus, Aigialus parvus BCC 5311. Structures of these compounds, including absolute configuration, were elucidated by spectroscopic methods, chemical conversions, and X-ray crystallographic analysis. Hypothemycin and aigialomycin D (5) exhibited in vitro antimalarial activity with IC50 values of 2.2 and 6.6 μg/mL, respectively, while other analogues were inactive. Cytotoxicities of these compounds were also evaluated.en_US
dc.identifier.citationJournal of Organic Chemistry. Vol.67, No.5 (2002), 1561-1566en_US
dc.identifier.doi10.1021/jo010930gen_US
dc.identifier.issn00223263en_US
dc.identifier.other2-s2.0-0037040681en_US
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/20.500.14594/20136
dc.rightsMahidol Universityen_US
dc.rights.holderSCOPUSen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0037040681&origin=inwarden_US
dc.subjectChemistryen_US
dc.titleAigialomycins A-E, new resorcylic macrolides from the marine mangrove fungus Aigialus parvusen_US
dc.typeArticleen_US
dspace.entity.typePublication
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0037040681&origin=inwarden_US

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