Publication: CYP2D6 genotype analysis of a Thai population: Platform comparison
Issued Date
2018-01-01
Resource Type
ISSN
17448042
14622416
14622416
Other identifier(s)
2-s2.0-85051119071
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Pharmacogenomics. Vol.19, No.12 (2018), 947-960
Suggested Citation
Monpat Chamnanphon, Andrea Gaedigk, Natchaya Vanwong, Nopphadol Nuntamool, Yaowaluck Hongkaew, Apichaya Puangpetch, Chonlaphat Sukasem CYP2D6 genotype analysis of a Thai population: Platform comparison. Pharmacogenomics. Vol.19, No.12 (2018), 947-960. doi:10.2217/pgs-2018-0075 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/45326
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
CYP2D6 genotype analysis of a Thai population: Platform comparison
Abstract
© 2018 Future Medicine Ltd. The highly polymorphic CYP2D6 gene locus leads to a wide range of enzyme activity. Since there are limited data for Thai, the major aim was to investigate CYP2D6 genetic variation in a large Thai population (n = 920). CYP2D6 genotyping was performed using four different platforms. Genotype call rates of the Luminex xTAG® and AmpliChip CYP450 test were 96.5% and 87.4%, respectively. Based on Luminex xTAG® data, the most common alleles and genotypes were ∗1 0 (49.6%), ∗1 (24.6%), ∗2 (10.8%), ∗5 (6.7%), ∗41 (6.5%) and ∗1/∗10 (23.9%), ∗10/∗10 (21.5%), ∗2/∗10 (9.4%), ∗5/∗10 (6.9%), ∗10/∗41 (5.7%), respectively. Challenges and limitations of the platforms evaluated are discussed. These data add to our knowledge regarding interethnic variability in CYP2D6 activity and contribute to improving drug therapy in the Thai.