Publication: CYP2D6 genotype analysis of a Thai population: Platform comparison
| dc.contributor.author | Monpat Chamnanphon | en_US |
| dc.contributor.author | Andrea Gaedigk | en_US |
| dc.contributor.author | Natchaya Vanwong | en_US |
| dc.contributor.author | Nopphadol Nuntamool | en_US |
| dc.contributor.author | Yaowaluck Hongkaew | en_US |
| dc.contributor.author | Apichaya Puangpetch | en_US |
| dc.contributor.author | Chonlaphat Sukasem | en_US |
| dc.contributor.other | Chulalongkorn University | en_US |
| dc.contributor.other | Faculty of Medicine, Ramathibodi Hospital, Mahidol University | en_US |
| dc.contributor.other | University of Missouri-Kansas City | en_US |
| dc.contributor.other | Payap University | en_US |
| dc.date.accessioned | 2019-08-23T10:41:07Z | |
| dc.date.available | 2019-08-23T10:41:07Z | |
| dc.date.issued | 2018-01-01 | en_US |
| dc.description.abstract | © 2018 Future Medicine Ltd. The highly polymorphic CYP2D6 gene locus leads to a wide range of enzyme activity. Since there are limited data for Thai, the major aim was to investigate CYP2D6 genetic variation in a large Thai population (n = 920). CYP2D6 genotyping was performed using four different platforms. Genotype call rates of the Luminex xTAG® and AmpliChip CYP450 test were 96.5% and 87.4%, respectively. Based on Luminex xTAG® data, the most common alleles and genotypes were ∗1 0 (49.6%), ∗1 (24.6%), ∗2 (10.8%), ∗5 (6.7%), ∗41 (6.5%) and ∗1/∗10 (23.9%), ∗10/∗10 (21.5%), ∗2/∗10 (9.4%), ∗5/∗10 (6.9%), ∗10/∗41 (5.7%), respectively. Challenges and limitations of the platforms evaluated are discussed. These data add to our knowledge regarding interethnic variability in CYP2D6 activity and contribute to improving drug therapy in the Thai. | en_US |
| dc.identifier.citation | Pharmacogenomics. Vol.19, No.12 (2018), 947-960 | en_US |
| dc.identifier.doi | 10.2217/pgs-2018-0075 | en_US |
| dc.identifier.issn | 17448042 | en_US |
| dc.identifier.issn | 14622416 | en_US |
| dc.identifier.other | 2-s2.0-85051119071 | en_US |
| dc.identifier.uri | https://repository.li.mahidol.ac.th/handle/20.500.14594/45326 | |
| dc.rights | Mahidol University | en_US |
| dc.rights.holder | SCOPUS | en_US |
| dc.source.uri | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85051119071&origin=inward | en_US |
| dc.subject | Biochemistry, Genetics and Molecular Biology | en_US |
| dc.subject | Pharmacology, Toxicology and Pharmaceutics | en_US |
| dc.title | CYP2D6 genotype analysis of a Thai population: Platform comparison | en_US |
| dc.type | Article | en_US |
| dspace.entity.type | Publication | |
| mu.datasource.scopus | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85051119071&origin=inward | en_US |