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Multiple populations of artemisinin-resistant Plasmodium falciparum in Cambodia

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dc.contributor.authorOlivo Miottoen_US
dc.contributor.authorJacob Almagro-Garciaen_US
dc.contributor.authorMagnus Manskeen_US
dc.contributor.authorBronwyn MacInnisen_US
dc.contributor.authorSusana Campinoen_US
dc.contributor.authorKirk A. Rocketten_US
dc.contributor.authorChanaki Amaratungaen_US
dc.contributor.authorPharath Limen_US
dc.contributor.authorSeila Suonen_US
dc.contributor.authorSokunthea Srengen_US
dc.contributor.authorJennifer M. Andersonen_US
dc.contributor.authorSocheat Duongen_US
dc.contributor.authorChea Nguonen_US
dc.contributor.authorChar Meng Chuoren_US
dc.contributor.authorDavid Saundersen_US
dc.contributor.authorYoury Seen_US
dc.contributor.authorChantap Lonen_US
dc.contributor.authorMark M. Fukudaen_US
dc.contributor.authorLucas Amenga-Etegoen_US
dc.contributor.authorAbraham V.O. Hodgsonen_US
dc.contributor.authorVictor Asoalaen_US
dc.contributor.authorMallika Imwongen_US
dc.contributor.authorShannon Takala-Harrisonen_US
dc.contributor.authorFrançois Nostenen_US
dc.contributor.authorXin Zhuan Suen_US
dc.contributor.authorPascal Ringwalden_US
dc.contributor.authorFrédéric Arieyen_US
dc.contributor.authorChristiane Doleceken_US
dc.contributor.authorTran Tinh Hienen_US
dc.contributor.authorMaciej F. Bonien_US
dc.contributor.authorCao Quang Thaien_US
dc.contributor.authorAlfred Amambua-Ngwaen_US
dc.contributor.authorDavid J. Conwayen_US
dc.contributor.authorAbdoulaye A. Djimdéen_US
dc.contributor.authorOgobara K. Doumboen_US
dc.contributor.authorIssaka Zongoen_US
dc.contributor.authorJean Bosco Ouedraogoen_US
dc.contributor.authorDaniel Alcocken_US
dc.contributor.authorEleanor Druryen_US
dc.contributor.authorSarah Auburnen_US
dc.contributor.authorOliver Kochen_US
dc.contributor.authorMandy Sandersen_US
dc.contributor.authorChristina Hubbarten_US
dc.contributor.authorGareth Maslenen_US
dc.contributor.authorValentin Ruano-Rubioen_US
dc.contributor.authorDushyanth Jyothien_US
dc.contributor.authorAlistair Milesen_US
dc.contributor.authorJohn O'Brienen_US
dc.contributor.authorChris Gambleen_US
dc.contributor.authorSamuel O. Oyolaen_US
dc.contributor.authorJulian C. Rayneren_US
dc.contributor.authorChris I. Newbolden_US
dc.contributor.authorMatthew Berrimanen_US
dc.contributor.authorChris C.A. Spenceren_US
dc.contributor.authorGilean McVeanen_US
dc.contributor.authorNicholas P. Dayen_US
dc.contributor.authorNicholas J. Whiteen_US
dc.contributor.authorDelia Bethellen_US
dc.contributor.authorArjen M. Dondorpen_US
dc.contributor.authorChristopher V. Ploween_US
dc.contributor.authorRick M. Fairhursten_US
dc.contributor.authorDominic P. Kwiatkowskien_US
dc.contributor.otherUniversity of Oxforden_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherWellcome Trust Sanger Instituteen_US
dc.contributor.otherWellcome Trust Centre for Human Geneticsen_US
dc.contributor.otherNational Institute of Allergy and Infectious Diseasesen_US
dc.contributor.otherNational Center for Parasitology, Entomology and Malaria Controlen_US
dc.contributor.otherArmed Forces Research Institute of Medical Sciences, Thailanden_US
dc.contributor.otherUSAMC-AFRIMSen_US
dc.contributor.otherArmed Forces Health Surveillance Centeren_US
dc.contributor.otherNavrongo Health Research Centeren_US
dc.contributor.otherUniversity of Maryland School of Medicineen_US
dc.contributor.otherShoklo Malaria Research Uniten_US
dc.contributor.otherOrganisation Mondiale de la Santeen_US
dc.contributor.otherInstitut Pasteur, Parisen_US
dc.contributor.otherOxford University Clinical Research Uniten_US
dc.contributor.otherMedical Research Council Laboratories Gambiaen_US
dc.contributor.otherLondon School of Hygiene & Tropical Medicineen_US
dc.contributor.otherUniversity of Sciencesen_US
dc.contributor.otherInstitut de Recherche en Sciences de la Santéen_US
dc.contributor.otherMenzies School of Health Researchen_US
dc.contributor.otherWeatherall Institute of Molecular Medicineen_US
dc.date.accessioned2018-10-19T04:39:20Z
dc.date.available2018-10-19T04:39:20Z
dc.date.issued2013-06-01en_US
dc.description.abstractWe describe an analysis of genome variation in 825 P. falciparum samples from Asia and Africa that identifies an unusual pattern of parasite population structure at the epicenter of artemisinin resistance in western Cambodia. Within this relatively small geographic area, we have discovered several distinct but apparently sympatric parasite subpopulations with extremely high levels of genetic differentiation. Of particular interest are three subpopulations, all associated with clinical resistance to artemisinin, which have skewed allele frequency spectra and high levels of haplotype homozygosity, indicative of founder effects and recent population expansion. We provide a catalog of SNPs that show high levels of differentiation in the artemisinin-resistant subpopulations, including codon variants in transporter proteins and DNA mismatch repair proteins. These data provide a population-level genetic framework for investigating the biological origins of artemisinin resistance and for defining molecular markers to assist in its elimination. © 2013 Nature America, Inc. All rights reserved.en_US
dc.identifier.citationNature Genetics. Vol.45, No.6 (2013), 648-655en_US
dc.identifier.doi10.1038/ng.2624en_US
dc.identifier.issn15461718en_US
dc.identifier.issn10614036en_US
dc.identifier.other2-s2.0-84878715473en_US
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/123456789/31306
dc.rightsMahidol Universityen_US
dc.rights.holderSCOPUSen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84878715473&origin=inwarden_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.titleMultiple populations of artemisinin-resistant Plasmodium falciparum in Cambodiaen_US
dc.typeArticleen_US
dspace.entity.typePublication
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84878715473&origin=inwarden_US

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