Publication: Synthesis and biological evaluation of isoflavone analogues from Dalbergia oliveri
Issued Date
2007-12-24
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ISSN
00404020
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2-s2.0-36148973932
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Mahidol University
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SCOPUS
Bibliographic Citation
Tetrahedron. Vol.63, No.52 (2007), 12986-12993
Suggested Citation
Sujittra Deesamer, Udom Kokpol, Warinthorn Chavasiri, Soazig Douillard, Vincent Peyrot, Nicolas Vidal, Sebastien Combes, Jean Pierre Finet Synthesis and biological evaluation of isoflavone analogues from Dalbergia oliveri. Tetrahedron. Vol.63, No.52 (2007), 12986-12993. doi:10.1016/j.tet.2007.10.030 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/24057
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Title
Synthesis and biological evaluation of isoflavone analogues from Dalbergia oliveri
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Abstract
Mucronulatol 1 and violanone 2 isolated from Dalbergia oliveri Gamble, and the corresponding isoflavone 3 were prepared by ligand coupling reactions involving organolead reagent. Biological studies have shown a significant cytotoxic effect against an HBL100 leukemia cell line only for isoflavan 1 with an IC50value amounting to 5.7 μM. All the drugs modestly inhibit the in vitro microtubule assembly, independently of the cytotoxic ability. Natural compounds 1 and 2 have no antibacterial activity, but are potent inhibitors of the Fusarium oxysporum phytopathogenic fungal growth. © 2007 Elsevier Ltd. All rights reserved.