Publication:
Genetic variability of Plasmodium malariae dihydropteroate synthase (dhps) in four Asian countries.

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tm-ar-mallika-2014-1.pdf (828.34 KB)

Accepted Date

2014-03-09

Issued Date

2014-04-03

Copyright Date

2014

Resource Type

Article

Language

eng

ISSN

1932-6203 (electronic)

DOI

10.1371/journal.pone.0093942.

Rights

Mahidol University

Rights Holder(s)

PLOS ONE

Bibliographic Citation

Tanomsing N, Mayxay M, Newton PN, Nosten F, Dolecek C, Hien TT. et al. Genetic variability of Plasmodium malariae dihydropteroate synthase (dhps) in four Asian countries. PLoS One. 2014 Apr 3;9(4):e93942.

Suggested Citation

Naowarat Tanomsing, เนาวรัตน์ ถนอมสิงห์, Mayxay, Mayfong, Newton, Paul N., Nosten, Francois, Dolecek, Christiane, Hien, Tran Tinh, White, Nicholas J., Day, Nicholas P. J., Dondorp, Arjen M., Mallika Imwong, มัลลิกา อิ่มวงศ์ Genetic variability of Plasmodium malariae dihydropteroate synthase (dhps) in four Asian countries.. Tanomsing N, Mayxay M, Newton PN, Nosten F, Dolecek C, Hien TT. et al. Genetic variability of Plasmodium malariae dihydropteroate synthase (dhps) in four Asian countries. PLoS One. 2014 Apr 3;9(4):e93942.. doi:10.1371/journal.pone.0093942. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/772

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Title

Genetic variability of Plasmodium malariae dihydropteroate synthase (dhps) in four Asian countries.

Author(s)

Naowarat Tanomsing
 เนาวรัตน์ ถนอมสิงห์
 Mayxay, Mayfong
 Newton, Paul N.
 Nosten, Francois
 Dolecek, Christiane
 Hien, Tran Tinh
 White, Nicholas J.
 Day, Nicholas P. J.
 Dondorp, Arjen M.
 Mallika Imwong
 มัลลิกา อิ่มวงศ์

Corresponding Author(s)

Mallika Imwong

Other Contributor(s)

Mahidol University. Faculty of Tropical Medicine. Department of Molecular Tropical Medicine and Genetics
 Mahidol University. Faculty of Tropical Medicine. Mahidol-Oxford Tropical Medicine Research Unit
 Mahidol University. Faculty of Tropical Medicine. Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Uni.

Abstract

The dihydropteroate synthase (dhps) genes of 44 P. malariae strains from four Asian countries were isolated. Only a limited number of polymorphisms were observed. Comparison with homologous mutations in other Plasmodium species showed that these polymorphisms are unlikely to be associated with sulfadoxine resistance.

Keyword(s)

Antimalarials
 DNA, Protozoan
 Plasmodium malariae
 Sulfadoxine
 Open Access article

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/772

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TM-Article