Publication: Differential expression of interferon-γ and interferon-γ- inducing cytokines in Thai patients with scrub typhus or leptospirosis
4
Issued Date
2004-11-01
Resource Type
ISSN
15216616
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2-s2.0-4644250419
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Mahidol University
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SCOPUS
Bibliographic Citation
Clinical Immunology. Vol.113, No.2 (2004), 140-144
Suggested Citation
Wirongrong Chierakul, Maaike De Fost, Yupin Suputtamongkol, Roongreung Limpaiboon, Arjen Dondorp, Nicholas J. White, Tom Van Der Poll Differential expression of interferon-γ and interferon-γ- inducing cytokines in Thai patients with scrub typhus or leptospirosis. Clinical Immunology. Vol.113, No.2 (2004), 140-144. doi:10.1016/j.clim.2004.08.006 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/21350
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Title
Differential expression of interferon-γ and interferon-γ- inducing cytokines in Thai patients with scrub typhus or leptospirosis
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Abstract
Interferon (IFN)-γ plays an important role in the induction of a type 1 immune response against intracellular pathogens. We compared the plasma levels of IFN-γ and IFN-γ-inducing cytokines in adult Thai patients with scrub typhus, caused by the obligate intracellular bacterium Orientia tsutsugamushi, and leptospirosis, caused by extracellular Leptospira interrogans. IFN-γ, interleukin (IL)-18, and IL-15 levels were elevated only in patients with scrub typhus, whereas IL-12p40 and tumor necrosis factor-α concentrations were elevated in both patient groups, although more so in scrub typhus. These data suggest a role for a cell-mediated immune response in host defense against O. tsutsugamushi. © 2004 Elsevier Inc. All rights reserved.