Publication: Differential expression of interferon-γ and interferon-γ- inducing cytokines in Thai patients with scrub typhus or leptospirosis
| dc.contributor.author | Wirongrong Chierakul | en_US |
| dc.contributor.author | Maaike De Fost | en_US |
| dc.contributor.author | Yupin Suputtamongkol | en_US |
| dc.contributor.author | Roongreung Limpaiboon | en_US |
| dc.contributor.author | Arjen Dondorp | en_US |
| dc.contributor.author | Nicholas J. White | en_US |
| dc.contributor.author | Tom Van Der Poll | en_US |
| dc.contributor.other | Mahidol University | en_US |
| dc.contributor.other | University of Amsterdam | en_US |
| dc.contributor.other | Udon Thani Rajabhat University | en_US |
| dc.contributor.other | John Radcliffe Hospital | en_US |
| dc.date.accessioned | 2018-07-24T03:42:28Z | |
| dc.date.available | 2018-07-24T03:42:28Z | |
| dc.date.issued | 2004-11-01 | en_US |
| dc.description.abstract | Interferon (IFN)-γ plays an important role in the induction of a type 1 immune response against intracellular pathogens. We compared the plasma levels of IFN-γ and IFN-γ-inducing cytokines in adult Thai patients with scrub typhus, caused by the obligate intracellular bacterium Orientia tsutsugamushi, and leptospirosis, caused by extracellular Leptospira interrogans. IFN-γ, interleukin (IL)-18, and IL-15 levels were elevated only in patients with scrub typhus, whereas IL-12p40 and tumor necrosis factor-α concentrations were elevated in both patient groups, although more so in scrub typhus. These data suggest a role for a cell-mediated immune response in host defense against O. tsutsugamushi. © 2004 Elsevier Inc. All rights reserved. | en_US |
| dc.identifier.citation | Clinical Immunology. Vol.113, No.2 (2004), 140-144 | en_US |
| dc.identifier.doi | 10.1016/j.clim.2004.08.006 | en_US |
| dc.identifier.issn | 15216616 | en_US |
| dc.identifier.other | 2-s2.0-4644250419 | en_US |
| dc.identifier.uri | https://repository.li.mahidol.ac.th/handle/20.500.14594/21350 | |
| dc.rights | Mahidol University | en_US |
| dc.rights.holder | SCOPUS | en_US |
| dc.source.uri | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=4644250419&origin=inward | en_US |
| dc.subject | Immunology and Microbiology | en_US |
| dc.subject | Medicine | en_US |
| dc.title | Differential expression of interferon-γ and interferon-γ- inducing cytokines in Thai patients with scrub typhus or leptospirosis | en_US |
| dc.type | Article | en_US |
| dspace.entity.type | Publication | |
| mu.datasource.scopus | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=4644250419&origin=inward | en_US |