Publication: Plasmodium vivax Relapse Rates following Plasmodium falciparum Malaria Reflect Previous Transmission Intensity
Issued Date
2019-06-05
Resource Type
ISSN
15376613
00221899
00221899
Other identifier(s)
2-s2.0-85067436321
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Infectious Diseases. Vol.220, No.1 (2019), 100-104
Suggested Citation
Elizabeth A. Ashley, Aung Pyae Phyo, Verena I. Carrara, Kyaw Myo Tun, Francois Nosten, Frank Smithuis, Nicholas J. White Plasmodium vivax Relapse Rates following Plasmodium falciparum Malaria Reflect Previous Transmission Intensity. Journal of Infectious Diseases. Vol.220, No.1 (2019), 100-104. doi:10.1093/infdis/jiz052 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/51594
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Plasmodium vivax Relapse Rates following Plasmodium falciparum Malaria Reflect Previous Transmission Intensity
Abstract
© 2019 The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. From 2003 through 2009, 687 of 2885 patients (23.8%) treated for Plasmodium falciparum malaria in clinical studies in Myanmar or on the Thailand-Myanmar border had recurrent Plasmodium vivax malaria within 63 days, compared with 18 of 429 patients (4.2%) from 2010 onward (risk ratio [RR], 0.176; 95% confidence interval,. 112-.278; P <. 0001). Corresponding data from 42 days of follow-up revealed that 820 of 3883 patients (21.1%) had recurrent P. vivax malaria before 2010, compared with 22 of 886 (2.5%) from 2010 onward (RR, 0.117; 95% CI,. 077-.177; P <. 0001). This 6-fold reduction suggests a recent decline in P. vivax transmission intensity and, thus, a substantial reduction in the proportion of individuals harboring hypnozoites.