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Plasmodium vivax Relapse Rates following Plasmodium falciparum Malaria Reflect Previous Transmission Intensity

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dc.contributor.authorElizabeth A. Ashleyen_US
dc.contributor.authorAung Pyae Phyoen_US
dc.contributor.authorVerena I. Carraraen_US
dc.contributor.authorKyaw Myo Tunen_US
dc.contributor.authorFrancois Nostenen_US
dc.contributor.authorFrank Smithuisen_US
dc.contributor.authorNicholas J. Whiteen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherNuffield Department of Clinical Medicineen_US
dc.contributor.otherMedical Action Myanmaren_US
dc.contributor.otherDefence Services Medical Academyen_US
dc.contributor.otherMyanmar Oxford Clinical Research Uniten_US
dc.date.accessioned2020-01-27T09:45:05Z
dc.date.available2020-01-27T09:45:05Z
dc.date.issued2019-06-05en_US
dc.description.abstract© 2019 The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. From 2003 through 2009, 687 of 2885 patients (23.8%) treated for Plasmodium falciparum malaria in clinical studies in Myanmar or on the Thailand-Myanmar border had recurrent Plasmodium vivax malaria within 63 days, compared with 18 of 429 patients (4.2%) from 2010 onward (risk ratio [RR], 0.176; 95% confidence interval,. 112-.278; P <. 0001). Corresponding data from 42 days of follow-up revealed that 820 of 3883 patients (21.1%) had recurrent P. vivax malaria before 2010, compared with 22 of 886 (2.5%) from 2010 onward (RR, 0.117; 95% CI,. 077-.177; P <. 0001). This 6-fold reduction suggests a recent decline in P. vivax transmission intensity and, thus, a substantial reduction in the proportion of individuals harboring hypnozoites.en_US
dc.identifier.citationJournal of Infectious Diseases. Vol.220, No.1 (2019), 100-104en_US
dc.identifier.doi10.1093/infdis/jiz052en_US
dc.identifier.issn15376613en_US
dc.identifier.issn00221899en_US
dc.identifier.other2-s2.0-85067436321en_US
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/20.500.14594/51594
dc.rightsMahidol Universityen_US
dc.rights.holderSCOPUSen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85067436321&origin=inwarden_US
dc.subjectMedicineen_US
dc.titlePlasmodium vivax Relapse Rates following Plasmodium falciparum Malaria Reflect Previous Transmission Intensityen_US
dc.typeArticleen_US
dspace.entity.typePublication
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85067436321&origin=inwarden_US

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