Publication:
Deferasirox in iron-overloaded patients with transfusion-dependent myelodysplastic syndromes: Results from the large 1-year EPIC study

Issued Date

2010-09-01

Resource Type

Article

ISSN

01452126

DOI

10.1016/j.leukres.2010.03.009

Other identifier(s)

2-s2.0-77955268192

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Leukemia Research. Vol.34, No.9 (2010), 1143-1150

Suggested Citation

Norbert Gattermann, Carlo Finelli, Matteo Della Porta, Pierre Fenaux, Arnold Ganser, Agnes Guerci-Bresler, Mathias Schmid, Kerry Taylor, Dominique Vassilieff, Dany Habr, Gabor Domokos, Bernard Roubert, Christian Rose, L. Agaoglu, G. Alimena, D. Alonso, S. Ame, E. Angelucci, B. Arrizabalaga, M. Athanasiou-Metaxa, B. Augustson, Y. Aydinok, A. Baba, M. Baccarani, J. Beck, P. Beris, O. Beyne-Rauzy, H. Birgens, D. Bordessoule, C. Borgna-Pignatti, A. Bosly, K. Bouabdallah, D. Bowden, D. Bowen, D. Bron, M. D. Cappellini, M. Capra, G. Cartron, M. Cazzola, C. Chalkias, L. L. Chan, S. Chancharunee, C. Chapman, P. Charoenkwan, E. Chasapopoulou, S. Cheze, A. Chuansumrit, P. Cianciulli, C. Dauriac, M. Delforge, G. Dölken, H. Dombret, J. Duyster, T. Economopoulos, G. Ehninger, M. Elalfy, A. El-Beshlawy, L. Enggaard, G. Fillet, A. Filosa, G. Forni, R. Galanello, G. Gastl, S. Giraudier, A. Goldfarb, A. Grigg, F. Gumruk, S. Y. Ha, D. Haase, B. Heinrich, M. Hertzberg, J. Ho, H. C. Hsu, S. Huang, M. Hunault-Berger, B. Inusa, D. Jaulmes, J. Jensen, A. Kattamis, Y. Kilinc, K. H. Kim, S. Kinsey, L. Kjeldsen, A. Koren, M. E. Lai, Y. Lai, J. W. Lee, K. H. Lee, S. H. Lee, L. Legros, C. Li, C. K. Li, Q. Li, K. H. Lin, W. Linkesch, M. Lübbert, D. Lutz, A. J. Mohamed Thalha, G. Mufti, P. Muus Deferasirox in iron-overloaded patients with transfusion-dependent myelodysplastic syndromes: Results from the large 1-year EPIC study. Leukemia Research. Vol.34, No.9 (2010), 1143-1150. doi:10.1016/j.leukres.2010.03.009 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/28652

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Title

Deferasirox in iron-overloaded patients with transfusion-dependent myelodysplastic syndromes: Results from the large 1-year EPIC study

Author(s)

Norbert Gattermann
 Carlo Finelli
 Matteo Della Porta
 Pierre Fenaux
 Arnold Ganser
 Agnes Guerci-Bresler
 Mathias Schmid
 Kerry Taylor
 Dominique Vassilieff
 Dany Habr
 Gabor Domokos
 Bernard Roubert
 Christian Rose
 L. Agaoglu
 G. Alimena
 D. Alonso
 S. Ame
 E. Angelucci
 B. Arrizabalaga
 M. Athanasiou-Metaxa
 B. Augustson
 Y. Aydinok
 A. Baba
 M. Baccarani
 J. Beck
 P. Beris
 O. Beyne-Rauzy
 H. Birgens
 D. Bordessoule
 C. Borgna-Pignatti
 A. Bosly
 K. Bouabdallah
 D. Bowden
 D. Bowen
 D. Bron
 M. D. Cappellini
 M. Capra
 G. Cartron
 M. Cazzola
 C. Chalkias
 L. L. Chan
 S. Chancharunee
 C. Chapman
 P. Charoenkwan
 E. Chasapopoulou
 S. Cheze
 A. Chuansumrit
 P. Cianciulli
 C. Dauriac
 M. Delforge
 G. Dölken
 H. Dombret
 J. Duyster
 T. Economopoulos
 G. Ehninger
 M. Elalfy
 A. El-Beshlawy
 L. Enggaard
 G. Fillet
 A. Filosa
 G. Forni
 R. Galanello
 G. Gastl
 S. Giraudier
 A. Goldfarb
 A. Grigg
 F. Gumruk
 S. Y. Ha
 D. Haase
 B. Heinrich
 M. Hertzberg
 J. Ho
 H. C. Hsu
 S. Huang
 M. Hunault-Berger
 B. Inusa
 D. Jaulmes
 J. Jensen
 A. Kattamis
 Y. Kilinc
 K. H. Kim
 S. Kinsey
 L. Kjeldsen
 A. Koren
 M. E. Lai
 Y. Lai
 J. W. Lee
 K. H. Lee
 S. H. Lee
 L. Legros
 C. Li
 C. K. Li
 Q. Li
 K. H. Lin
 W. Linkesch
 M. Lübbert
 D. Lutz
 A. J. Mohamed Thalha
 G. Mufti
 P. Muus

Other Contributor(s)

Heinrich Heine Universitat
 Alma Mater Studiorum Universita di Bologna
 Universita degli Studi di Pavia
 Hopital Avicenne
 Medizinische Hochschule Hannover (MHH)
 Hopital Brabois Adultes
 Universitatsklinikum Ulm
 Mater Hospital
 Universite Paris Descartes
 Novartis Pharmaceuticals
 Novartis International AG
 Hopital Saint Vincent-de-Paul GHICL
 Istanbul Universitesi
 Azienda Policlinico Umberto I
 Hospital Universitario Virgen del Rocio
 Hopital de Hautepierre
 Azienda Ospedaliera Brotzu - Businco
 Hospital de Cruzes
 Aristotle University of Thessaloniki
 Sir Charles Gairdner Hospital
 Ege Universitesi
 Hospital Universiti Sains Malaysia
 Osp. Bologna
 Klinikum der Johannes-Gutenberg-Universitat und Fachbereich Medizin
 Hopitaux universitaires de Geneve
 Hopital Purpan
 Amtssygehusetl Herlev
 CHU de Limoges
 Az. Ospedaliera Universitaria St. Anna
 Cliniques Universitaires UCL
 CHU Hopitaux de Bordeaux
 Monash Medical Centre
 Leeds General Infirmary
 Institut Jules Bordet
 Universita degli Studi di Milano
 Ospedale Civico M. Ascoli
 Clinique Victor Hugo
 Fondazione IRCCS Policlinico San Matteo
 Larissa General Hospital
 University of Malaya Medical Centre
 Mahidol University
 Leicester Royal Infirmary
 Chiang Mai University
 University Hospitalof Thessaloniki AHEPA
 Hopital Clemenceau
 Ospedale S. Eugenio
 Hopital Pontchaillou
 KU Leuven– University Hospital Leuven
 Ernst-Moritz-Arndt-Universitat Greifswald
 Hopital Saint-Louis
 Technical University of Munich
 University of Athens Medical School
 Dresden University Faculty of Medicine and University Hospital Carl Gustav Carus
 Ain Shams University
 Cairo University
 Hillerod Hospital
 Centre Hospitalier Universitaire de Liege
 Azienda Ospedaliera Di Rilievo Nazionale Antonio Cardarelli
 E.O. Ospedali Galliera
 Azienda Ospedaliera Brotzu - Microcitemico
 Medizinische Universitat Innsbruck
 Hopital Henri Mondor
 Hadassah University Medical Centre
 Royal Melbourne Hospital
 Hacettepe Universitesi
 Queen Mary Hospital Hong Kong
 Universitatsmedizin Gottingen
 Gemeinschaftspraxis Brudler/ Heinrich
 Westmead Hospital
 Royal Prince Alfred Hospital
 Veterans General Hospital-Taipei
 Guang Zhou Zhong Shan No.2 Hospital
 CHU Angers
 Evelina Children's Hospital
 Hopital Saint-Antoine
 Aarhus Amtssygehus, Aarhus University Hospital
 University of Athens
 Cukurova Universitesi
 Samsung Medical Center, Sungkyunkwan University
 St James's University Hospital
 Rigshospitalet
 Emek Medical Center
 Hospital of Nanjing Medical University
 The Catholic University of Korea
 Asan Medical Center
 Royal Adelaide Hospital
 Centre Hospitalier Universitaire de Nice, Hopital l'Archet
 Nanfang Hospital
 Prince of Wales Hospital Hong Kong
 Branch of Shanghai No.1 Hospital
 National Taiwan University Hospital
 LKH-Universitatsklinikum Graz
 Universitats Klinikum Freiburg und Medizinische Fakultat
 A. Ö. Krankenhausder Elisabethinen
 Hospital Universiti Kebangsaan Malaysia
 King's College Hospital NHS Foundation Trust
 Radboud University Nijmegen Medical Centre

Abstract

The prospective 1-year EPIC study enrolled 341 patients with myelodysplastic syndromes (MDS); although baseline iron burden was >2500. ng/mL, ∼50% were chelation-naïve. Overall median serum ferritin decreased significantly at 1 year (p=0.002). Decreases occurred irrespective of whether patients were chelation-naïve or previously chelated; changes were dependent on dose adjustments and ongoing iron intake. Sustained reductions in labile plasma iron were observed. Discontinuation rate (48.7%) and adverse event profile were consistent with previously reported deferasirox data in MDS. Alanine aminotransferase levels decreased significantly; change correlated significantly with reduction in serum ferritin (p<0.0001). This large dataset prospectively confirms the efficacy and well characterizes the safety profile of deferasirox in MDS. © 2010 Elsevier Ltd.

Keyword(s)

Biochemistry, Genetics and Molecular Biology
 Medicine

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/28652

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Scopus 2006-2010