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Deferasirox in iron-overloaded patients with transfusion-dependent myelodysplastic syndromes: Results from the large 1-year EPIC study

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dc.contributor.authorNorbert Gattermannen_US
dc.contributor.authorCarlo Finellien_US
dc.contributor.authorMatteo Della Portaen_US
dc.contributor.authorPierre Fenauxen_US
dc.contributor.authorArnold Ganseren_US
dc.contributor.authorAgnes Guerci-Bresleren_US
dc.contributor.authorMathias Schmiden_US
dc.contributor.authorKerry Tayloren_US
dc.contributor.authorDominique Vassilieffen_US
dc.contributor.authorDany Habren_US
dc.contributor.authorGabor Domokosen_US
dc.contributor.authorBernard Rouberten_US
dc.contributor.authorChristian Roseen_US
dc.contributor.authorL. Agaogluen_US
dc.contributor.authorG. Alimenaen_US
dc.contributor.authorD. Alonsoen_US
dc.contributor.authorS. Ameen_US
dc.contributor.authorE. Angeluccien_US
dc.contributor.authorB. Arrizabalagaen_US
dc.contributor.authorM. Athanasiou-Metaxaen_US
dc.contributor.authorB. Augustsonen_US
dc.contributor.authorY. Aydinoken_US
dc.contributor.authorA. Babaen_US
dc.contributor.authorM. Baccaranien_US
dc.contributor.authorJ. Becken_US
dc.contributor.authorP. Berisen_US
dc.contributor.authorO. Beyne-Rauzyen_US
dc.contributor.authorH. Birgensen_US
dc.contributor.authorD. Bordessouleen_US
dc.contributor.authorC. Borgna-Pignattien_US
dc.contributor.authorA. Boslyen_US
dc.contributor.authorK. Bouabdallahen_US
dc.contributor.authorD. Bowdenen_US
dc.contributor.authorD. Bowenen_US
dc.contributor.authorD. Bronen_US
dc.contributor.authorM. D. Cappellinien_US
dc.contributor.authorM. Capraen_US
dc.contributor.authorG. Cartronen_US
dc.contributor.authorM. Cazzolaen_US
dc.contributor.authorC. Chalkiasen_US
dc.contributor.authorL. L. Chanen_US
dc.contributor.authorS. Chancharuneeen_US
dc.contributor.authorC. Chapmanen_US
dc.contributor.authorP. Charoenkwanen_US
dc.contributor.authorE. Chasapopoulouen_US
dc.contributor.authorS. Chezeen_US
dc.contributor.authorA. Chuansumriten_US
dc.contributor.authorP. Cianciullien_US
dc.contributor.authorC. Dauriacen_US
dc.contributor.authorM. Delforgeen_US
dc.contributor.authorG. Dölkenen_US
dc.contributor.authorH. Dombreten_US
dc.contributor.authorJ. Duysteren_US
dc.contributor.authorT. Economopoulosen_US
dc.contributor.authorG. Ehningeren_US
dc.contributor.authorM. Elalfyen_US
dc.contributor.authorA. El-Beshlawyen_US
dc.contributor.authorL. Enggaarden_US
dc.contributor.authorG. Filleten_US
dc.contributor.authorA. Filosaen_US
dc.contributor.authorG. Fornien_US
dc.contributor.authorR. Galanelloen_US
dc.contributor.authorG. Gastlen_US
dc.contributor.authorS. Giraudieren_US
dc.contributor.authorA. Goldfarben_US
dc.contributor.authorA. Griggen_US
dc.contributor.authorF. Gumruken_US
dc.contributor.authorS. Y. Haen_US
dc.contributor.authorD. Haaseen_US
dc.contributor.authorB. Heinrichen_US
dc.contributor.authorM. Hertzbergen_US
dc.contributor.authorJ. Hoen_US
dc.contributor.authorH. C. Hsuen_US
dc.contributor.authorS. Huangen_US
dc.contributor.authorM. Hunault-Bergeren_US
dc.contributor.authorB. Inusaen_US
dc.contributor.authorD. Jaulmesen_US
dc.contributor.authorJ. Jensenen_US
dc.contributor.authorA. Kattamisen_US
dc.contributor.authorY. Kilincen_US
dc.contributor.authorK. H. Kimen_US
dc.contributor.authorS. Kinseyen_US
dc.contributor.authorL. Kjeldsenen_US
dc.contributor.authorA. Korenen_US
dc.contributor.authorM. E. Laien_US
dc.contributor.authorY. Laien_US
dc.contributor.authorJ. W. Leeen_US
dc.contributor.authorK. H. Leeen_US
dc.contributor.authorS. H. Leeen_US
dc.contributor.authorL. Legrosen_US
dc.contributor.authorC. Lien_US
dc.contributor.authorC. K. Lien_US
dc.contributor.authorQ. Lien_US
dc.contributor.authorK. H. Linen_US
dc.contributor.authorW. Linkeschen_US
dc.contributor.authorM. Lübberten_US
dc.contributor.authorD. Lutzen_US
dc.contributor.authorA. J. Mohamed Thalhaen_US
dc.contributor.authorG. Muftien_US
dc.contributor.authorP. Muusen_US
dc.contributor.otherHeinrich Heine Universitaten_US
dc.contributor.otherAlma Mater Studiorum Universita di Bolognaen_US
dc.contributor.otherUniversita degli Studi di Paviaen_US
dc.contributor.otherHopital Avicenneen_US
dc.contributor.otherMedizinische Hochschule Hannover (MHH)en_US
dc.contributor.otherHopital Brabois Adultesen_US
dc.contributor.otherUniversitatsklinikum Ulmen_US
dc.contributor.otherMater Hospitalen_US
dc.contributor.otherUniversite Paris Descartesen_US
dc.contributor.otherNovartis Pharmaceuticalsen_US
dc.contributor.otherNovartis International AGen_US
dc.contributor.otherHopital Saint Vincent-de-Paul GHICLen_US
dc.contributor.otherIstanbul Universitesien_US
dc.contributor.otherAzienda Policlinico Umberto Ien_US
dc.contributor.otherHospital Universitario Virgen del Rocioen_US
dc.contributor.otherHopital de Hautepierreen_US
dc.contributor.otherAzienda Ospedaliera Brotzu - Busincoen_US
dc.contributor.otherHospital de Cruzesen_US
dc.contributor.otherAristotle University of Thessalonikien_US
dc.contributor.otherSir Charles Gairdner Hospitalen_US
dc.contributor.otherEge Universitesien_US
dc.contributor.otherHospital Universiti Sains Malaysiaen_US
dc.contributor.otherOsp. Bolognaen_US
dc.contributor.otherKlinikum der Johannes-Gutenberg-Universitat und Fachbereich Medizinen_US
dc.contributor.otherHopitaux universitaires de Geneveen_US
dc.contributor.otherHopital Purpanen_US
dc.contributor.otherAmtssygehusetl Herleven_US
dc.contributor.otherCHU de Limogesen_US
dc.contributor.otherAz. Ospedaliera Universitaria St. Annaen_US
dc.contributor.otherCliniques Universitaires UCLen_US
dc.contributor.otherCHU Hopitaux de Bordeauxen_US
dc.contributor.otherMonash Medical Centreen_US
dc.contributor.otherLeeds General Infirmaryen_US
dc.contributor.otherInstitut Jules Bordeten_US
dc.contributor.otherUniversita degli Studi di Milanoen_US
dc.contributor.otherOspedale Civico M. Ascolien_US
dc.contributor.otherClinique Victor Hugoen_US
dc.contributor.otherFondazione IRCCS Policlinico San Matteoen_US
dc.contributor.otherLarissa General Hospitalen_US
dc.contributor.otherUniversity of Malaya Medical Centreen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherLeicester Royal Infirmaryen_US
dc.contributor.otherChiang Mai Universityen_US
dc.contributor.otherUniversity Hospitalof Thessaloniki AHEPAen_US
dc.contributor.otherHopital Clemenceauen_US
dc.contributor.otherOspedale S. Eugenioen_US
dc.contributor.otherHopital Pontchaillouen_US
dc.contributor.otherKU Leuven– University Hospital Leuvenen_US
dc.contributor.otherErnst-Moritz-Arndt-Universitat Greifswalden_US
dc.contributor.otherHopital Saint-Louisen_US
dc.contributor.otherTechnical University of Munichen_US
dc.contributor.otherUniversity of Athens Medical Schoolen_US
dc.contributor.otherDresden University Faculty of Medicine and University Hospital Carl Gustav Carusen_US
dc.contributor.otherAin Shams Universityen_US
dc.contributor.otherCairo Universityen_US
dc.contributor.otherHillerod Hospitalen_US
dc.contributor.otherCentre Hospitalier Universitaire de Liegeen_US
dc.contributor.otherAzienda Ospedaliera Di Rilievo Nazionale Antonio Cardarellien_US
dc.contributor.otherE.O. Ospedali Gallieraen_US
dc.contributor.otherAzienda Ospedaliera Brotzu - Microcitemicoen_US
dc.contributor.otherMedizinische Universitat Innsbrucken_US
dc.contributor.otherHopital Henri Mondoren_US
dc.contributor.otherHadassah University Medical Centreen_US
dc.contributor.otherRoyal Melbourne Hospitalen_US
dc.contributor.otherHacettepe Universitesien_US
dc.contributor.otherQueen Mary Hospital Hong Kongen_US
dc.contributor.otherUniversitatsmedizin Gottingenen_US
dc.contributor.otherGemeinschaftspraxis Brudler/ Heinrichen_US
dc.contributor.otherWestmead Hospitalen_US
dc.contributor.otherRoyal Prince Alfred Hospitalen_US
dc.contributor.otherVeterans General Hospital-Taipeien_US
dc.contributor.otherGuang Zhou Zhong Shan No.2 Hospitalen_US
dc.contributor.otherCHU Angersen_US
dc.contributor.otherEvelina Children's Hospitalen_US
dc.contributor.otherHopital Saint-Antoineen_US
dc.contributor.otherAarhus Amtssygehus, Aarhus University Hospitalen_US
dc.contributor.otherUniversity of Athensen_US
dc.contributor.otherCukurova Universitesien_US
dc.contributor.otherSamsung Medical Center, Sungkyunkwan Universityen_US
dc.contributor.otherSt James's University Hospitalen_US
dc.contributor.otherRigshospitaleten_US
dc.contributor.otherEmek Medical Centeren_US
dc.contributor.otherHospital of Nanjing Medical Universityen_US
dc.contributor.otherThe Catholic University of Koreaen_US
dc.contributor.otherAsan Medical Centeren_US
dc.contributor.otherRoyal Adelaide Hospitalen_US
dc.contributor.otherCentre Hospitalier Universitaire de Nice, Hopital l'Archeten_US
dc.contributor.otherNanfang Hospitalen_US
dc.contributor.otherPrince of Wales Hospital Hong Kongen_US
dc.contributor.otherBranch of Shanghai No.1 Hospitalen_US
dc.contributor.otherNational Taiwan University Hospitalen_US
dc.contributor.otherLKH-Universitatsklinikum Grazen_US
dc.contributor.otherUniversitats Klinikum Freiburg und Medizinische Fakultaten_US
dc.contributor.otherA. Ö. Krankenhausder Elisabethinenen_US
dc.contributor.otherHospital Universiti Kebangsaan Malaysiaen_US
dc.contributor.otherKing's College Hospital NHS Foundation Trusten_US
dc.contributor.otherRadboud University Nijmegen Medical Centreen_US
dc.date.accessioned2018-09-24T08:43:16Z
dc.date.available2018-09-24T08:43:16Z
dc.date.issued2010-09-01en_US
dc.description.abstractThe prospective 1-year EPIC study enrolled 341 patients with myelodysplastic syndromes (MDS); although baseline iron burden was >2500. ng/mL, ∼50% were chelation-naïve. Overall median serum ferritin decreased significantly at 1 year (p=0.002). Decreases occurred irrespective of whether patients were chelation-naïve or previously chelated; changes were dependent on dose adjustments and ongoing iron intake. Sustained reductions in labile plasma iron were observed. Discontinuation rate (48.7%) and adverse event profile were consistent with previously reported deferasirox data in MDS. Alanine aminotransferase levels decreased significantly; change correlated significantly with reduction in serum ferritin (p<0.0001). This large dataset prospectively confirms the efficacy and well characterizes the safety profile of deferasirox in MDS. © 2010 Elsevier Ltd.en_US
dc.identifier.citationLeukemia Research. Vol.34, No.9 (2010), 1143-1150en_US
dc.identifier.doi10.1016/j.leukres.2010.03.009en_US
dc.identifier.issn01452126en_US
dc.identifier.other2-s2.0-77955268192en_US
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/20.500.14594/28652
dc.rightsMahidol Universityen_US
dc.rights.holderSCOPUSen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=77955268192&origin=inwarden_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.subjectMedicineen_US
dc.titleDeferasirox in iron-overloaded patients with transfusion-dependent myelodysplastic syndromes: Results from the large 1-year EPIC studyen_US
dc.typeArticleen_US
dspace.entity.typePublication
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=77955268192&origin=inwarden_US

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