Publication: Juice of Eclipta prostrata inhibits cell migration in vitro and exhibits anti-angiogenic activity in vivo
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2008-05-01
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0258851X
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2-s2.0-45949087186
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Mahidol University
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SCOPUS
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In Vivo. Vol.22, No.3 (2008), 363-368
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Kriengsak Lirdprapamongkol, Jan Peter Kramb, Daranee Chokchaichamnankit, Chantragan Srisomsap, Rudee Surarit, Monnipha Sila-Asna, Ahnond Bunyaratvej, Gerd Danhardt, Jisnuson Svasti Juice of Eclipta prostrata inhibits cell migration in vitro and exhibits anti-angiogenic activity in vivo. In Vivo. Vol.22, No.3 (2008), 363-368. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/19683
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Juice of Eclipta prostrata inhibits cell migration in vitro and exhibits anti-angiogenic activity in vivo
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Background: The invasion of cancer cells is critical for metastasis. The effects of Eclipta prostrata, a Thai medicinal plant, on invasion, migration and adhesion of cancer cells were investigated and:i the anti-angiogenic activity in vivo was evaluated. Materials and methods: In vitro invasion and migration assays were performed in modified Boyden chambers. In vivo anti-angiogenic activity was determined using the chick chorioallantoic membrane (CAM) assay. Results: E. prostrata juice inhibited cancer invasion and migration, without affecting cell adhesion. Cell migration was inhibited in a variety of cancer cell types and in endothelial cells, with IC50 values of 31-70 μg/ml, much lower than the IC50 values for cytotoxicity of 203-1,217 μg/ml for cancer cells and >4,000 μg/ml for endothelial cells. Fifty percent inhibition of angiogenesis by E. prostrata juice was observed at 200 μg/egg. Conclusion: E. prostrata juice inhibited cancer and endothelial cell migration in vitro and also showed in vivo anti-angiogenic activity.