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Juice of Eclipta prostrata inhibits cell migration in vitro and exhibits anti-angiogenic activity in vivo

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dc.contributor.authorKriengsak Lirdprapamongkolen_US
dc.contributor.authorJan Peter Kramben_US
dc.contributor.authorDaranee Chokchaichamnankiten_US
dc.contributor.authorChantragan Srisomsapen_US
dc.contributor.authorRudee Surariten_US
dc.contributor.authorMonnipha Sila-Asnaen_US
dc.contributor.authorAhnond Bunyaratvejen_US
dc.contributor.authorGerd Danhardten_US
dc.contributor.authorJisnuson Svastien_US
dc.contributor.otherChulabhorn Research Instituteen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherJohannes Gutenberg Universitat Mainzen_US
dc.contributor.otherThe Institute of Science and Technology for Research and Development, Mahidol Universityen_US
dc.date.accessioned2018-07-12T02:43:25Z
dc.date.available2018-07-12T02:43:25Z
dc.date.issued2008-05-01en_US
dc.description.abstractBackground: The invasion of cancer cells is critical for metastasis. The effects of Eclipta prostrata, a Thai medicinal plant, on invasion, migration and adhesion of cancer cells were investigated and:i the anti-angiogenic activity in vivo was evaluated. Materials and methods: In vitro invasion and migration assays were performed in modified Boyden chambers. In vivo anti-angiogenic activity was determined using the chick chorioallantoic membrane (CAM) assay. Results: E. prostrata juice inhibited cancer invasion and migration, without affecting cell adhesion. Cell migration was inhibited in a variety of cancer cell types and in endothelial cells, with IC50 values of 31-70 μg/ml, much lower than the IC50 values for cytotoxicity of 203-1,217 μg/ml for cancer cells and >4,000 μg/ml for endothelial cells. Fifty percent inhibition of angiogenesis by E. prostrata juice was observed at 200 μg/egg. Conclusion: E. prostrata juice inhibited cancer and endothelial cell migration in vitro and also showed in vivo anti-angiogenic activity.en_US
dc.identifier.citationIn Vivo. Vol.22, No.3 (2008), 363-368en_US
dc.identifier.issn0258851Xen_US
dc.identifier.other2-s2.0-45949087186en_US
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/20.500.14594/19683
dc.rightsMahidol Universityen_US
dc.rights.holderSCOPUSen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=45949087186&origin=inwarden_US
dc.subjectMedicineen_US
dc.titleJuice of Eclipta prostrata inhibits cell migration in vitro and exhibits anti-angiogenic activity in vivoen_US
dc.typeArticleen_US
dspace.entity.typePublication
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=45949087186&origin=inwarden_US

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