Publication:
Complete NMR assignment and absolute configuration of k4610422, a norditerpenoid inhibitor of testosterone-5α-reductase originally from Streptosporangium: rediscovery from a thermophilic Actinomadura

Issued Date

2020-01-01

Resource Type

Article

ISSN

18811469
00218820

DOI

10.1038/s41429-019-0231-7

Other identifier(s)

2-s2.0-85072167335

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Journal of Antibiotics. Vol.73, No.1 (2020), 60-65

Suggested Citation

Hirofumi Akiyama, Naoya Oku, Enjuro Harunari, Watanalai Panbangred, Yasuhiro Igarashi Complete NMR assignment and absolute configuration of k4610422, a norditerpenoid inhibitor of testosterone-5α-reductase originally from Streptosporangium: rediscovery from a thermophilic Actinomadura. Journal of Antibiotics. Vol.73, No.1 (2020), 60-65. doi:10.1038/s41429-019-0231-7 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/49686

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Title

Complete NMR assignment and absolute configuration of k4610422, a norditerpenoid inhibitor of testosterone-5α-reductase originally from Streptosporangium: rediscovery from a thermophilic Actinomadura

Author(s)

Hirofumi Akiyama
 Naoya Oku
 Enjuro Harunari
 Watanalai Panbangred
 Yasuhiro Igarashi

Other Contributor(s)

Toyama Prefectural University
 Mahidol University

Abstract

© 2019, The Author(s), under exclusive licence to the Japan Antibiotics Research Association. A norditerpenoid k4610422 (1), an inhibitor of testosterone-5α-reductase originally discovered from a mesophilic rare actinomycete of the genus Streptosporangium, was isolated from the culture extract of a thermophilic actinomycete Actinomadura sp. The complete 1H and 13C NMR assignment and absolute configuration of 1 were addressed by spectroscopic measurements including NOESY and CD spectra coupled with ECD calculation, which allowed to establish the (5 R,9 S,10 R,13 S)-configuration. Compound 1 was moderately cytotoxic against P388 murine leukemia cells with IC50 30 μM.

Keyword(s)

Pharmacology, Toxicology and Pharmaceutics

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/49686

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Scopus 2020