Publication: Complete NMR assignment and absolute configuration of k4610422, a norditerpenoid inhibitor of testosterone-5α-reductase originally from Streptosporangium: rediscovery from a thermophilic Actinomadura
| dc.contributor.author | Hirofumi Akiyama | en_US |
| dc.contributor.author | Naoya Oku | en_US |
| dc.contributor.author | Enjuro Harunari | en_US |
| dc.contributor.author | Watanalai Panbangred | en_US |
| dc.contributor.author | Yasuhiro Igarashi | en_US |
| dc.contributor.other | Toyama Prefectural University | en_US |
| dc.contributor.other | Mahidol University | en_US |
| dc.date.accessioned | 2020-01-27T03:38:45Z | |
| dc.date.available | 2020-01-27T03:38:45Z | |
| dc.date.issued | 2020-01-01 | en_US |
| dc.description.abstract | © 2019, The Author(s), under exclusive licence to the Japan Antibiotics Research Association. A norditerpenoid k4610422 (1), an inhibitor of testosterone-5α-reductase originally discovered from a mesophilic rare actinomycete of the genus Streptosporangium, was isolated from the culture extract of a thermophilic actinomycete Actinomadura sp. The complete 1H and 13C NMR assignment and absolute configuration of 1 were addressed by spectroscopic measurements including NOESY and CD spectra coupled with ECD calculation, which allowed to establish the (5 R,9 S,10 R,13 S)-configuration. Compound 1 was moderately cytotoxic against P388 murine leukemia cells with IC50 30 μM. | en_US |
| dc.identifier.citation | Journal of Antibiotics. Vol.73, No.1 (2020), 60-65 | en_US |
| dc.identifier.doi | 10.1038/s41429-019-0231-7 | en_US |
| dc.identifier.issn | 18811469 | en_US |
| dc.identifier.issn | 00218820 | en_US |
| dc.identifier.other | 2-s2.0-85072167335 | en_US |
| dc.identifier.uri | https://repository.li.mahidol.ac.th/handle/20.500.14594/49686 | |
| dc.rights | Mahidol University | en_US |
| dc.rights.holder | SCOPUS | en_US |
| dc.source.uri | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85072167335&origin=inward | en_US |
| dc.subject | Pharmacology, Toxicology and Pharmaceutics | en_US |
| dc.title | Complete NMR assignment and absolute configuration of k4610422, a norditerpenoid inhibitor of testosterone-5α-reductase originally from Streptosporangium: rediscovery from a thermophilic Actinomadura | en_US |
| dc.type | Article | en_US |
| dspace.entity.type | Publication | |
| mu.datasource.scopus | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85072167335&origin=inward | en_US |