Publication:
Generation of a human induced pluripotent stem cell line (MUi010-A) from skin fibroblast of patient carrying a c.2104C>T mutation in MYH9 gene

Issued Date

2019-04-01

Resource Type

Article

ISSN

18767753
18735061

DOI

10.1016/j.scr.2019.101397

Other identifier(s)

2-s2.0-85061823358

Rights

Mahidol University

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SCOPUS

Bibliographic Citation

Stem Cell Research. Vol.36, (2019)

Suggested Citation

Amornrat Tangprasittipap, Bunyada Jittorntrum, Praguywan Kadegasem, Werasak Sasanakul, Nongnuch Sirachainan, Narisorn Kitiyanant, Suradej Hongeng Generation of a human induced pluripotent stem cell line (MUi010-A) from skin fibroblast of patient carrying a c.2104C>T mutation in MYH9 gene. Stem Cell Research. Vol.36, (2019). doi:10.1016/j.scr.2019.101397 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/50207

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Title

Generation of a human induced pluripotent stem cell line (MUi010-A) from skin fibroblast of patient carrying a c.2104C>T mutation in MYH9 gene

Author(s)

Amornrat Tangprasittipap
 Bunyada Jittorntrum
 Praguywan Kadegasem
 Werasak Sasanakul
 Nongnuch Sirachainan
 Narisorn Kitiyanant
 Suradej Hongeng

Other Contributor(s)

Faculty of Medicine, Ramathibodi Hospital, Mahidol University
 Mahidol University

Abstract

© 2019 Mutations in MYH9 gene is one of the major causes of inherited thrombocytopenia resulted from nonfunctional myosin-9 protein. We have generated a human induced pluripotent stem cell line MUi010-A from skin fibroblasts of a patient who had a point mutation c.2104C>T (p.R702C) in the exon 16 of MYH9 gene using a non-integrative reprogramming method. The MUi010-A exhibited embryonic stem cell-like characteristics with consistent pluripotent markers expression, was capable of all three embryonic germ layers differentiation, and had a normal karyotype.

Keyword(s)

Biochemistry, Genetics and Molecular Biology

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/50207

Collections

Scopus 2019