Publication:
Dioscorealides and dioscoreanone, novel cytotoxic naphthofuranoxepins, and 1,4-phenanthraquinone from Dioscorea membranacea Pierre

1

Issued Date

2003-08-07

Resource Type

Article

ISSN

15237060

DOI

10.1021/ol034926y

Other identifier(s)

2-s2.0-0141631703

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Organic Letters. Vol.5, No.16 (2003), 2879-2882

Suggested Citation

Arunporn Itharat, Anuchit Plubrukarn, Palangpon Kongsaeree, Tam Bui, Niwat Keawpradub, Peter J. Houghton Dioscorealides and dioscoreanone, novel cytotoxic naphthofuranoxepins, and 1,4-phenanthraquinone from Dioscorea membranacea Pierre. Organic Letters. Vol.5, No.16 (2003), 2879-2882. doi:10.1021/ol034926y Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/20702

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Title

Dioscorealides and dioscoreanone, novel cytotoxic naphthofuranoxepins, and 1,4-phenanthraquinone from Dioscorea membranacea Pierre

Author(s)

Arunporn Itharat
 Anuchit Plubrukarn
 Palangpon Kongsaeree
 Tam Bui
 Niwat Keawpradub
 Peter J. Houghton

Other Contributor(s)

King's College London
 Prince of Songkla University
 Mahidol University

Abstract

(Matrix presented) Commonly used among ingredients in Thai traditional anticancer preparations, the rhizome of Dioscorea membranacea Pierre was found potently cytotoxic and possibly contributed to such a therapeutic effect. Bioassay-guided isolation resulted in two novel cytotoxic naphthofuranoxepins, dioscorealides A (1) and B (2), and a new 1,4-phenanthraquinone, dioscoreanone (3). The structure determination, achieved mainly by means of NMR and CD spectral and X-ray crystallographic analyses, and cytotoxicity are discussed here.

Keyword(s)

Biochemistry, Genetics and Molecular Biology
 Chemistry

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URI

https://repository.li.mahidol.ac.th/handle/123456789/20702

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Scopus 2001-2005