Publication: Inhibitory effect of Thai plant extracts on P-glycoprotein mediated efflux
Issued Date
2006-01-01
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ISSN
10991573
0951418X
0951418X
DOI
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2-s2.0-31644449339
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Mahidol University
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SCOPUS
Bibliographic Citation
Phytotherapy Research. Vol.20, No.1 (2006), 79-81
Suggested Citation
Varaporn Buraphacheep Junyaprasert, Noppamas Soonthornchareonnon, Suchitra Thongpraditchote, Teruo Murakami, Mikihisa Takano Inhibitory effect of Thai plant extracts on P-glycoprotein mediated efflux. Phytotherapy Research. Vol.20, No.1 (2006), 79-81. doi:10.1002/ptr.1785 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/23185
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Title
Inhibitory effect of Thai plant extracts on P-glycoprotein mediated efflux
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Abstract
Curcuminoids from Curcuma longa L. and extracts of Psidium guajava L., Andrographis paniculata (Burm. f.) Nees, Phyllanthus emblica L. and Solanum trilobatum L. were investigated for their inhibitory effect on P-glycoprotein (P-gp) on the efflux transport of rhodamine 123 (Rho-123) in Caco-2 cells and rat ileum. Of the five tested samples, curcuminoids and an extract of P. guajava showed the highest inhibitory effect on P-gp mediated efflux of Rho-123 in Caco-2 cells. Additionally, they were found to have equal potential in inhibiting Rho-123 efflux transport from serosal to mucosal surfaces of the rat ileum. Copyright © 2006 John Wiley & Sons, Ltd.