Publication: Inhibitory effect of Thai plant extracts on P-glycoprotein mediated efflux
| dc.contributor.author | Varaporn Buraphacheep Junyaprasert | en_US |
| dc.contributor.author | Noppamas Soonthornchareonnon | en_US |
| dc.contributor.author | Suchitra Thongpraditchote | en_US |
| dc.contributor.author | Teruo Murakami | en_US |
| dc.contributor.author | Mikihisa Takano | en_US |
| dc.contributor.other | Mahidol University | en_US |
| dc.contributor.other | Hiroshima University | en_US |
| dc.date.accessioned | 2018-08-20T06:56:53Z | |
| dc.date.available | 2018-08-20T06:56:53Z | |
| dc.date.issued | 2006-01-01 | en_US |
| dc.description.abstract | Curcuminoids from Curcuma longa L. and extracts of Psidium guajava L., Andrographis paniculata (Burm. f.) Nees, Phyllanthus emblica L. and Solanum trilobatum L. were investigated for their inhibitory effect on P-glycoprotein (P-gp) on the efflux transport of rhodamine 123 (Rho-123) in Caco-2 cells and rat ileum. Of the five tested samples, curcuminoids and an extract of P. guajava showed the highest inhibitory effect on P-gp mediated efflux of Rho-123 in Caco-2 cells. Additionally, they were found to have equal potential in inhibiting Rho-123 efflux transport from serosal to mucosal surfaces of the rat ileum. Copyright © 2006 John Wiley & Sons, Ltd. | en_US |
| dc.identifier.citation | Phytotherapy Research. Vol.20, No.1 (2006), 79-81 | en_US |
| dc.identifier.doi | 10.1002/ptr.1785 | en_US |
| dc.identifier.issn | 10991573 | en_US |
| dc.identifier.issn | 0951418X | en_US |
| dc.identifier.other | 2-s2.0-31644449339 | en_US |
| dc.identifier.uri | https://repository.li.mahidol.ac.th/handle/20.500.14594/23185 | |
| dc.rights | Mahidol University | en_US |
| dc.rights.holder | SCOPUS | en_US |
| dc.source.uri | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=31644449339&origin=inward | en_US |
| dc.subject | Chemistry | en_US |
| dc.subject | Pharmacology, Toxicology and Pharmaceutics | en_US |
| dc.title | Inhibitory effect of Thai plant extracts on P-glycoprotein mediated efflux | en_US |
| dc.type | Article | en_US |
| dspace.entity.type | Publication | |
| mu.datasource.scopus | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=31644449339&origin=inward | en_US |