Publication: Depsidones and an α-pyrone derivative from Simpilcillium sp. PSU-H41, an endophytic fungus from Hevea brasiliensis leaf
Issued Date
2017-11-01
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ISSN
00319422
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2-s2.0-85026908528
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Mahidol University
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SCOPUS
Bibliographic Citation
Phytochemistry. Vol.143, (2017), 115-123
Suggested Citation
Praphatsorn Saetang, Vatcharin Rukachaisirikul, Souwalak Phongpaichit, Sita Preedanon, Jariya Sakayaroj, Suparerk Borwornpinyo, Sawinee Seemakhan, Chatchai Muanprasat Depsidones and an α-pyrone derivative from Simpilcillium sp. PSU-H41, an endophytic fungus from Hevea brasiliensis leaf. Phytochemistry. Vol.143, (2017), 115-123. doi:10.1016/j.phytochem.2017.08.002 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/41309
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Title
Depsidones and an α-pyrone derivative from Simpilcillium sp. PSU-H41, an endophytic fungus from Hevea brasiliensis leaf
Abstract
© 2017 Elsevier Ltd Nine previously undescribed depsidones (simplicildones A-I) and one previously undescribed α-pyrone (simplicilopyrone) were isolated from the endophytic fungus Simplicillium sp. PSU-H41 along with 11 known compounds. Their structures were established by extensive spectroscopic analysis. Simplicildone A and known botryorhodine C displayed weak antibacterial against Staphylococcus aureus with equal MIC values of 32 μg/mL. Additionally, botryorhodine C was active against methicillin-resistant S. aureus with the same MIC value. Simplicildone C exhibited weak antifungal activity against Cryptococcus neoformans with an MIC value of 32 μg/mL. In addition, simplicildones A and C and botryorhodine C were noncytotoxic against noncancerous Vero cells.