Publication:
Impaired interaction of α-haemoglobin-stabilising protein with α-globin termination mutant in a yeast two-hybrid system

Issued Date

2006-02-01

Resource Type

Article

ISSN

13652141
00071048

DOI

10.1111/j.1365-2141.2005.05865.x

Other identifier(s)

2-s2.0-33644868959

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

British Journal of Haematology. Vol.132, No.3 (2006), 370-373

Suggested Citation

Chairat Turbpaiboon, Thawornchai Limjindaporn, Wiyada Wongwiwat, Yaowalak U-Pratya, Noppadol Siritanaratkul, Pa Thai Yenchitsomanus, Sarawut Jitrapakdee, Prapon Wilairat Impaired interaction of α-haemoglobin-stabilising protein with α-globin termination mutant in a yeast two-hybrid system. British Journal of Haematology. Vol.132, No.3 (2006), 370-373. doi:10.1111/j.1365-2141.2005.05865.x Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/23824

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Title

Impaired interaction of α-haemoglobin-stabilising protein with α-globin termination mutant in a yeast two-hybrid system

Author(s)

Chairat Turbpaiboon
 Thawornchai Limjindaporn
 Wiyada Wongwiwat
 Yaowalak U-Pratya
 Noppadol Siritanaratkul
 Pa Thai Yenchitsomanus
 Sarawut Jitrapakdee
 Prapon Wilairat

Other Contributor(s)

Mahidol University

Abstract

α-Thalassaemia caused by α-globin gene termination codon mutations (αT-globin) has been explained by their inherent mRNA instability and by oxidative damage arising from the presence of membrane-bound αT-globin chains. To better understand the latter phenomenon, a yeast two-hybrid system was used to assay the interaction between αT-globin and its molecular chaperone, α-haemoglobin- stabilising protein (AHSP) and impaired binding of αT-globin with AHSP compared with αwild-type-globin was observed. © 2005 Blackwell Publishing Ltd.

Keyword(s)

Medicine

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/23824

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Scopus 2006-2010