Publication: New ansamycins from the deep-sea-derived bacterium ochrobactrum sp. OUCMDZ-2164
Issued Date
2018-08-15
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ISSN
16603397
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2-s2.0-85053718332
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Mahidol University
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SCOPUS
Bibliographic Citation
Marine Drugs. Vol.16, No.8 (2018)
Suggested Citation
Yaqin Fan, Cong Wang, Liping Wang, Arthit Chairoungdua, Pawinee Piyachaturawat, Peng Fu, Weiming Zhu New ansamycins from the deep-sea-derived bacterium ochrobactrum sp. OUCMDZ-2164. Marine Drugs. Vol.16, No.8 (2018). doi:10.3390/md16080282 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/47302
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Title
New ansamycins from the deep-sea-derived bacterium ochrobactrum sp. OUCMDZ-2164
Abstract
© 2018 by the authors. All Rights Reserved. Two new ansamycins, trienomycins H (1) and I (2), together with the known trienomycinol (3), were isolated from the fermentation broth of the deep-sea-derived bacterium Ochrobactrum sp. OUCMDZ-2164. Their structures, including their absolute configurations, were elucidated based on spectroscopic analyses, ECD spectra, and Marfey’s method. Compound 1 exhibited cytotoxic effects on A549 and K562 cell lines with IC 50 values of 15 and 23 µM, respectively.