Publication: Anti-HIV-1 Limonoid: First Isolation from Clausena excavata
Issued Date
2003-11-01
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ISSN
0951418X
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Other identifier(s)
2-s2.0-10744223641
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Mahidol University
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SCOPUS
Bibliographic Citation
Phytotherapy Research. Vol.17, No.9 (2003), 1101-1103
Suggested Citation
Arunrat Sunthitikawinsakul, Ngampong Kongkathip, Boonsong Kongkathip, Sida Phonnakhu, John W. Daly, Thomas F. Spande, Yuth Nimit, Chanita Napaswat, Jittra Kasisit, Chalobon Yoosook Anti-HIV-1 Limonoid: First Isolation from Clausena excavata. Phytotherapy Research. Vol.17, No.9 (2003), 1101-1103. doi:10.1002/ptr.1381 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/21023
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Title
Anti-HIV-1 Limonoid: First Isolation from Clausena excavata
Abstract
A limonoid, clausenolide-1-ethyl ether (1) and two coumarins, dentatin (2) and nor-dentatin (3), were isolated from Clausena excavata. Limonoid 1 was obtained from the crude ethanol extract of the rhizomes and the roots but had not previously been isolated from C. excavata and exhibited HIV-1 inhibitory activity. Coumarins 2 and 3, with their structures related to an anti-HIV-1 substance, (+)-calanolide A (4), were obtained from the crude chloroform extract of the rhizomes. Both induced toxicity to cells used in a syncytium assay for anti-HIV-1 activity. These compounds, 1-3, did not show any cytotoxic effect against KB and BC-1 cell lines (IC50value > 20 μg/mL). Copyright © 2003 John Wiley & Sons, Ltd.