Publication: Anti-HIV-1 Limonoid: First Isolation from Clausena excavata
| dc.contributor.author | Arunrat Sunthitikawinsakul | en_US |
| dc.contributor.author | Ngampong Kongkathip | en_US |
| dc.contributor.author | Boonsong Kongkathip | en_US |
| dc.contributor.author | Sida Phonnakhu | en_US |
| dc.contributor.author | John W. Daly | en_US |
| dc.contributor.author | Thomas F. Spande | en_US |
| dc.contributor.author | Yuth Nimit | en_US |
| dc.contributor.author | Chanita Napaswat | en_US |
| dc.contributor.author | Jittra Kasisit | en_US |
| dc.contributor.author | Chalobon Yoosook | en_US |
| dc.contributor.other | Kasetsart University | en_US |
| dc.contributor.other | National Institute of Diabetes and Digestive and Kidney Diseases | en_US |
| dc.contributor.other | Mahidol University | en_US |
| dc.date.accessioned | 2018-07-24T03:29:02Z | |
| dc.date.available | 2018-07-24T03:29:02Z | |
| dc.date.issued | 2003-11-01 | en_US |
| dc.description.abstract | A limonoid, clausenolide-1-ethyl ether (1) and two coumarins, dentatin (2) and nor-dentatin (3), were isolated from Clausena excavata. Limonoid 1 was obtained from the crude ethanol extract of the rhizomes and the roots but had not previously been isolated from C. excavata and exhibited HIV-1 inhibitory activity. Coumarins 2 and 3, with their structures related to an anti-HIV-1 substance, (+)-calanolide A (4), were obtained from the crude chloroform extract of the rhizomes. Both induced toxicity to cells used in a syncytium assay for anti-HIV-1 activity. These compounds, 1-3, did not show any cytotoxic effect against KB and BC-1 cell lines (IC50value > 20 μg/mL). Copyright © 2003 John Wiley & Sons, Ltd. | en_US |
| dc.identifier.citation | Phytotherapy Research. Vol.17, No.9 (2003), 1101-1103 | en_US |
| dc.identifier.doi | 10.1002/ptr.1381 | en_US |
| dc.identifier.issn | 0951418X | en_US |
| dc.identifier.other | 2-s2.0-10744223641 | en_US |
| dc.identifier.uri | https://repository.li.mahidol.ac.th/handle/20.500.14594/21023 | |
| dc.rights | Mahidol University | en_US |
| dc.rights.holder | SCOPUS | en_US |
| dc.source.uri | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=10744223641&origin=inward | en_US |
| dc.subject | Pharmacology, Toxicology and Pharmaceutics | en_US |
| dc.title | Anti-HIV-1 Limonoid: First Isolation from Clausena excavata | en_US |
| dc.type | Article | en_US |
| dspace.entity.type | Publication | |
| mu.datasource.scopus | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=10744223641&origin=inward | en_US |