Publication: Cytotoxic sesquiterpenes from luminescent mushroom Neonothopanus nambi
Issued Date
2012-09-30
Resource Type
ISSN
14645416
00404020
00404020
Other identifier(s)
2-s2.0-84865064882
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Mahidol University
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SCOPUS
Bibliographic Citation
Tetrahedron. Vol.68, No.39 (2012), 8261-8266
Suggested Citation
Somdej Kanokmedhakul, Ratsami Lekphrom, Kwanjai Kanokmedhakul, Chariya Hahnvajanawong, Sureeporn Bua-Art, Weerasak Saksirirat, Samran Prabpai, Palangpon Kongsaeree Cytotoxic sesquiterpenes from luminescent mushroom Neonothopanus nambi. Tetrahedron. Vol.68, No.39 (2012), 8261-8266. doi:10.1016/j.tet.2012.07.057 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/13608
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Title
Cytotoxic sesquiterpenes from luminescent mushroom Neonothopanus nambi
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Abstract
Four new aristolane sesquiterpenes named nambinones A-C (1-3) and 1-epi-nambinone B (4), a new sesquiterpene, nambinone D (5), a known compound, aurisin A (6) as well as a new dimeric sesquiterpene, aurisin K (7), were isolated from two isolates of luminescent mushroom, Neonothopanus nambi, PW1 and PW2. These structures were established on the basis of spectroscopic evidence. The relative configuration of 6 was determined by X-ray crystallographic analysis. Compounds 6 and 7 exhibited antimalarial activity against Plasmodium falciparum and antimycobacterial activity against Mycobacterium tuberculosis. Compounds 3, 6, and 7 showed cytotoxicity against NCI-H187 cancer cell lines. In addition, 6 and 7 showed cytotoxicity against the cholangiocarcinoma cell lines. © 2012 Elsevier Ltd. All rights reserved.