Publication: Release of granzymes and chemokines in Thai patients with leptospirosis
Issued Date
2007-01-01
Resource Type
ISSN
14690691
1198743X
1198743X
Other identifier(s)
2-s2.0-33847795928
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Clinical Microbiology and Infection. Vol.13, No.4 (2007), 433-436
Suggested Citation
M. De Fost, W. Chierakul, R. Limpaiboon, A. Dondorp, N. J. White, T. Van Der Poll Release of granzymes and chemokines in Thai patients with leptospirosis. Clinical Microbiology and Infection. Vol.13, No.4 (2007), 433-436. doi:10.1111/j.1469-0691.2006.01640.x Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/25081
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Title
Release of granzymes and chemokines in Thai patients with leptospirosis
Abstract
The plasma concentrations of granzymes are considered to reflect the involvement of cytotoxic T-cells and natural killer cells in various disease states. Interferon (IFN)-γ-inducible protein-10 (IP-10) and monokine induced by IFN-γ (Mig) are members of the non-ELR CXC chemokine family that act on T-cells and natural killer cells. This study revealed that the plasma concentrations of granzyme B (but not granzyme A), IP-10 and Mig were higher in 44 Thai patients with definite or possible leptospirosis than in healthy blood donors. These data suggest that activation of cell-mediated immunity is part of the early host response to leptospirosis. © 2007 European Society of Clinical Microbiology and Infectious Diseases.