Publication:
Stimulation of Ca<sup>2+</sup>uptake in the human liver fluke Opisthorchis viverrini by praziquantel

Issued Date

1983-05-30

Resource Type

Article

ISSN

00243205

DOI

10.1016/0024-3205(83)90234-5

Other identifier(s)

2-s2.0-0020646133

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Life Sciences. Vol.32, No.22 (1983), 2529-2534

Suggested Citation

Pintip Ruenwongsa, Nongporn Hutadilok, Yongyuth Yuthavong Stimulation of Ca<sup>2+</sup>uptake in the human liver fluke Opisthorchis viverrini by praziquantel. Life Sciences. Vol.32, No.22 (1983), 2529-2534. doi:10.1016/0024-3205(83)90234-5 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/30547

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Title

Stimulation of Ca<sup>2+</sup>uptake in the human liver fluke Opisthorchis viverrini by praziquantel

Author(s)

Pintip Ruenwongsa
 Nongporn Hutadilok
 Yongyuth Yuthavong

Other Contributor(s)

Mahidol University

Abstract

45Ca2+uptake by the human liver fluke Opisthorchis viverrini is enhanced by praziquantel. The drug-induced45Ca2+uptake was dependent on the presence of Ca2+and was attenuated in the presence of 10 mM Mg2+. La3+and vanadate at concentration of 1mM partially reduced the amount of45Ca2+uptake into the liver fluke in response to praziquantel treatment. The stimulating effect of praziquantel was eliminated in the presence of 10 μM verapamil. These findings suggest that praziquantel increases the permeability of the liver fluke tegument to Ca2+probably by interfering with the mechanism that regulates Ca2+binding or trnasport across the tegumental membrane. © 1983.

Keyword(s)

Pharmacology, Toxicology and Pharmaceutics

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URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/30547

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Scopus 1969-1990