Publication:
Stimulation of Ca<sup>2+</sup>uptake in the human liver fluke Opisthorchis viverrini by praziquantel

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dc.contributor.authorPintip Ruenwongsaen_US
dc.contributor.authorNongporn Hutadiloken_US
dc.contributor.authorYongyuth Yuthavongen_US
dc.contributor.otherMahidol Universityen_US
dc.date.accessioned2018-10-12T07:37:38Z
dc.date.available2018-10-12T07:37:38Z
dc.date.issued1983-05-30en_US
dc.description.abstract45Ca2+uptake by the human liver fluke Opisthorchis viverrini is enhanced by praziquantel. The drug-induced45Ca2+uptake was dependent on the presence of Ca2+and was attenuated in the presence of 10 mM Mg2+. La3+and vanadate at concentration of 1mM partially reduced the amount of45Ca2+uptake into the liver fluke in response to praziquantel treatment. The stimulating effect of praziquantel was eliminated in the presence of 10 μM verapamil. These findings suggest that praziquantel increases the permeability of the liver fluke tegument to Ca2+probably by interfering with the mechanism that regulates Ca2+binding or trnasport across the tegumental membrane. © 1983.en_US
dc.identifier.citationLife Sciences. Vol.32, No.22 (1983), 2529-2534en_US
dc.identifier.doi10.1016/0024-3205(83)90234-5en_US
dc.identifier.issn00243205en_US
dc.identifier.other2-s2.0-0020646133en_US
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/20.500.14594/30547
dc.rightsMahidol Universityen_US
dc.rights.holderSCOPUSen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0020646133&origin=inwarden_US
dc.subjectPharmacology, Toxicology and Pharmaceuticsen_US
dc.titleStimulation of Ca<sup>2+</sup>uptake in the human liver fluke Opisthorchis viverrini by praziquantelen_US
dc.typeArticleen_US
dspace.entity.typePublication
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0020646133&origin=inwarden_US

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