Publication:
Short report: Dihydroartemisinin - Piperaquine rescue treatment of multidrug-resistant Plasmodium falciparum malaria in pregnancy: A preliminary report

Issued Date

2008-04-01

Resource Type

Article

ISSN

00029637

Other identifier(s)

2-s2.0-45349085248

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

American Journal of Tropical Medicine and Hygiene. Vol.78, No.4 (2008), 543-545

Suggested Citation

Marcus J. Rijken, Rose McGready, Machteld E. Boel, Marion Barends, Stephane Proux, Mupawjay Pimanpanarak, Pratap Singhasivanon, François Nosten Short report: Dihydroartemisinin - Piperaquine rescue treatment of multidrug-resistant Plasmodium falciparum malaria in pregnancy: A preliminary report. American Journal of Tropical Medicine and Hygiene. Vol.78, No.4 (2008), 543-545. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/19347

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Title

Short report: Dihydroartemisinin - Piperaquine rescue treatment of multidrug-resistant Plasmodium falciparum malaria in pregnancy: A preliminary report

Author(s)

Marcus J. Rijken
 Rose McGready
 Machteld E. Boel
 Marion Barends
 Stephane Proux
 Mupawjay Pimanpanarak
 Pratap Singhasivanon
 François Nosten

Other Contributor(s)

Shoklo Malaria Research Unit
 Mahidol University

Abstract

Dihydroartemisinin-piperaquine (DHA-PPQ) is a promising new artemisinin combination treatment. There are no published data on the intentional use of the drug in pregnancy. Between June 2006 and January 2007, 50 Karen pregnant women with recurrent P. falciparum infections, despite 7-day treatments with quinine or artesunate (+/-clindamycin) or both, were treated with DHA-PPQ. This rescue treatment was effective and well tolerated and there was no evidence of toxicity for the mothers or the fetus. The PCR adjusted cure rate by Kaplan Meier analysis at day 63 was 92.2% (95% CI: 76.9-97.4). Copyright © 2008 by The American Society of Tropical Medicine and Hygiene.

Keyword(s)

Immunology and Microbiology
 Medicine

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/19347

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