Publication: Antiplasmodial, antimycobacterial, and cytotoxic principles from Camchaya calcarea
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Issued Date
2006-12-01
Resource Type
ISSN
00320943
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2-s2.0-33846213131
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Mahidol University
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SCOPUS
Bibliographic Citation
Planta Medica. Vol.72, No.15 (2006), 1427-1430
Suggested Citation
Namphung Vongvanich, Prasat Kittakoop, Panarat Charoenchai, Sutichai Intamas, Kanlayanee Sriklung, Yodhathai Thebtaranonth Antiplasmodial, antimycobacterial, and cytotoxic principles from Camchaya calcarea. Planta Medica. Vol.72, No.15 (2006), 1427-1430. doi:10.1055/s-2006-951711 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/22853
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Title
Antiplasmodial, antimycobacterial, and cytotoxic principles from Camchaya calcarea
Abstract
Chemical exploration of Camchaya calcarea (family Compositae) has led to the isolation of nine known sesquiterpene lactones 1-9, together with caffeic acid methyl ester 10. Sesquiterpenes 1, 2, 3, 4, 5, 7, and 8 exhibited moderate antiplasmodial activity, but showed potent antimycobacterial activity. Interestingly, the cytotoxicity of sesquiterpene lactones 1, 2, and 4 towards small-cell lung cancer cell line (NCI-H187) is stronger (two orders of magnitude) than towards the Vero cell line. Caffeic acid methyl ester (10) was cytotoxic against NCI-H187 and BC cell lines, however the ester 10 showed only mild antimycobacterial activity. © Georg Thieme Verlag KG Stuttgart.