Publication: Antiplasmodial, antimycobacterial, and cytotoxic principles from Camchaya calcarea
Issued Date
2006-12-01
Resource Type
ISSN
00320943
Other identifier(s)
2-s2.0-33846213131
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Planta Medica. Vol.72, No.15 (2006), 1427-1430
Suggested Citation
Namphung Vongvanich, Prasat Kittakoop, Panarat Charoenchai, Sutichai Intamas, Kanlayanee Sriklung, Yodhathai Thebtaranonth Antiplasmodial, antimycobacterial, and cytotoxic principles from Camchaya calcarea. Planta Medica. Vol.72, No.15 (2006), 1427-1430. doi:10.1055/s-2006-951711 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/22853
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Antiplasmodial, antimycobacterial, and cytotoxic principles from Camchaya calcarea
Abstract
Chemical exploration of Camchaya calcarea (family Compositae) has led to the isolation of nine known sesquiterpene lactones 1-9, together with caffeic acid methyl ester 10. Sesquiterpenes 1, 2, 3, 4, 5, 7, and 8 exhibited moderate antiplasmodial activity, but showed potent antimycobacterial activity. Interestingly, the cytotoxicity of sesquiterpene lactones 1, 2, and 4 towards small-cell lung cancer cell line (NCI-H187) is stronger (two orders of magnitude) than towards the Vero cell line. Caffeic acid methyl ester (10) was cytotoxic against NCI-H187 and BC cell lines, however the ester 10 showed only mild antimycobacterial activity. © Georg Thieme Verlag KG Stuttgart.