Publication:
Pyrrolidine and α-methylene-α-lactam from the cyclization of α-(alkylaminoethyl)acrylate: Synthesis of aza-sarkomycins

Issued Date

1987-01-01

Resource Type

Article

ISSN

00404039

DOI

10.1016/S0040-4039(00)96943-0

Other identifier(s)

2-s2.0-0023579210

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Tetrahedron Letters. Vol.28, No.52 (1987), 6675-6678

Suggested Citation

Bonkoch Tarnchompoo, Chachanat Thebtaranonth, Yodhathai Thebtaranonth Pyrrolidine and α-methylene-α-lactam from the cyclization of α-(alkylaminoethyl)acrylate: Synthesis of aza-sarkomycins. Tetrahedron Letters. Vol.28, No.52 (1987), 6675-6678. doi:10.1016/S0040-4039(00)96943-0 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/15321

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Title

Pyrrolidine and α-methylene-α-lactam from the cyclization of α-(alkylaminoethyl)acrylate: Synthesis of aza-sarkomycins

Author(s)

Bonkoch Tarnchompoo
 Chachanat Thebtaranonth
 Yodhathai Thebtaranonth

Other Contributor(s)

Mahidol University

Abstract

Diene 1 readily adds primary amines to give 2 which can cyclize either in a Michael addition fashion or via a displacement reaction to give, respectively, pyrrolidine 3 or methylene lactam 4 which further isomerizes to 5 under the employed reaction conditions. Compound 4 can be obtained as the sole product from the reaction of diene precursor 7 with amines followed by vacuum pyrolysis. © 1987.

Keyword(s)

Biochemistry, Genetics and Molecular Biology
 Chemistry
 Pharmacology, Toxicology and Pharmaceutics

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https://repository.li.mahidol.ac.th/handle/20.500.14594/15321

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Scopus 1969-1990