Publication: No evidence of cardiotoxicity during antimalarial treatment with artemether-lumefantrine
Issued Date
1999-01-01
Resource Type
ISSN
00029637
Other identifier(s)
2-s2.0-0033386669
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Mahidol University
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SCOPUS
Bibliographic Citation
American Journal of Tropical Medicine and Hygiene. Vol.61, No.6 (1999), 964-967
Suggested Citation
M. Van Vugt, F. Ezzet, F. Nosten, I. Gathmann, P. Wilairatana, S. Looareesuwan, N. J. White No evidence of cardiotoxicity during antimalarial treatment with artemether-lumefantrine. American Journal of Tropical Medicine and Hygiene. Vol.61, No.6 (1999), 964-967. doi:10.4269/ajtmh.1999.61.964 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/25476
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Title
No evidence of cardiotoxicity during antimalarial treatment with artemether-lumefantrine
Abstract
Artemether-lumefantrine is a new fixed antimalarial combination effective against multidrug-resistant falciparum malaria. A prospective electrocardiographic study was conducted in 150 patients receiving artemether-lumefantrine and 50 treated with artesunate-mefloquine. There was no evidence for clinically significant changes in the electrocardiographic intervals and in particular no relationship between plasma concentrations of lumefantrine and QTc prolongation. Artemether-lumefantrine does not have significant cardiac effects at therapeutic doses.