Publication: 3D Printing of Microgel-Loaded Modular Microcages as Instructive Scaffolds for Tissue Engineering
Issued Date
2020-01-01
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ISSN
15214095
09359648
09359648
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2-s2.0-85088316709
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Mahidol University
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SCOPUS
Bibliographic Citation
Advanced Materials. (2020)
Suggested Citation
Ramesh Subbiah, Christina Hipfinger, Anthony Tahayeri, Avathamsa Athirasala, Sivaporn Horsophonphong, Greeshma Thrivikraman, Cristiane Miranda França, Diana Araujo Cunha, Amin Mansoorifar, Albena Zahariev, James M. Jones, Paulo G. Coelho, Lukasz Witek, Hua Xie, Robert E. Guldberg, Luiz E. Bertassoni 3D Printing of Microgel-Loaded Modular Microcages as Instructive Scaffolds for Tissue Engineering. Advanced Materials. (2020). doi:10.1002/adma.202001736 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/57902
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Title
3D Printing of Microgel-Loaded Modular Microcages as Instructive Scaffolds for Tissue Engineering
Abstract
© 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Biomaterial scaffolds have served as the foundation of tissue engineering and regenerative medicine. However, scaffold systems are often difficult to scale in size or shape in order to fit defect-specific dimensions, and thus provide only limited spatiotemporal control of therapeutic delivery and host tissue responses. Here, a lithography-based 3D printing strategy is used to fabricate a novel miniaturized modular microcage scaffold system, which can be assembled and scaled manually with ease. Scalability is based on an intuitive concept of stacking modules, like conventional toy interlocking plastic blocks, allowing for literally thousands of potential geometric configurations, and without the need for specialized equipment. Moreover, the modular hollow-microcage design allows each unit to be loaded with biologic cargo of different compositions, thus enabling controllable and easy patterning of therapeutics within the material in 3D. In summary, the concept of miniaturized microcage designs with such straight-forward assembly and scalability, as well as controllable loading properties, is a flexible platform that can be extended to a wide range of materials for improved biological performance.