Publication: Validation of osteoporosis risk assessment tools in middle-aged Thai women
Issued Date
2016-11-01
Resource Type
ISSN
14730804
13697137
13697137
Other identifier(s)
2-s2.0-84988603394
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Climacteric. Vol.19, No.6 (2016), 588-593
Suggested Citation
S. Indhavivadhana, M. Rattanachaiyanont, S. Angsuwathana, K. Techatraisak, P. Tanmahasamut, P. Leerasiri Validation of osteoporosis risk assessment tools in middle-aged Thai women. Climacteric. Vol.19, No.6 (2016), 588-593. doi:10.1080/13697137.2016.1231176 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/41013
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Validation of osteoporosis risk assessment tools in middle-aged Thai women
Other Contributor(s)
Abstract
© 2016 International Menopause Society. Objectives: To validate osteoporosis risk assessment tools in middle-aged Thai women. Methods: A total of 1038 women who had bone mineral density (BMD) measurements using dual-energy X-ray absorptiometry were reviewed. Clinical data were used to validate the diagnostic test performance of various osteoporosis risk assessment tools, including ABONE, FRAX®, ORAI, OSIRIS, SCORE, SOFSURF, and OSTA. The following parameters were evaluated: sensitivity, specificity, negative predictive value (NPV), positive predictive value (PPV), and accuracy; those with 95% confidence interval (CI) of the receiver operator characteristics area under the curve (ROC-AUC) > 0.5 were considered statistically significant. Results: The subjects had a mean age of 53.01 ± 6.20 years and body mass index (BMI) of 23.98 ± 3.38 kg/m2. Among the osteoporosis risk assessment tools being evaluated, the tools that had ROC-AUC >0.8 and 95% CI >0.5, and could predict osteoporosis at the femoral neck with high specificity of >75% and NPV of >90%, were FRAX® without BMD (ROC-AUC 0.83; 95% CI 0.73–0.93; specificity 99.90; NPV 98.89), SCORE (ROC-AUC 0.86; 95% CI 0.78–0.94; specificity 98.79; NPV 98.99), and OSTA (ROC-AUC 0.86; 95% CI 0.79–0.94; specificity 75.03; NPV 99.73). Conclusion: The prevalence of osteoporosis in the middle-aged Thai women attending Siriraj Menopause Clinic is 7.3% at the lumbar spine and/or femoral neck. FRAX® without BMD, SCORE, and OSTA have appropriate validity as tools for ruling out osteoporosis in these women.