Publication: Distribution of C14-labelled arteether in kidneys and livers of experimental mice after intramuscular injection
2
Issued Date
2008-03-01
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ISSN
01251562
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2-s2.0-42349086514
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Mahidol University
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SCOPUS
Bibliographic Citation
Southeast Asian Journal of Tropical Medicine and Public Health. Vol.39, No.2 (2008), 195-199
Suggested Citation
Cheeraratana Cheeramakara, Vasant Khachonsaksumet, Nopachai Suthisai, Wanyarat Nakosiri, Kriyaporn Songmuaeng, Channarong Saenghirun, Duangduen Phienpicharn, Apichart Nontprasert Distribution of C14-labelled arteether in kidneys and livers of experimental mice after intramuscular injection. Southeast Asian Journal of Tropical Medicine and Public Health. Vol.39, No.2 (2008), 195-199. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/19730
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Title
Distribution of C14-labelled arteether in kidneys and livers of experimental mice after intramuscular injection
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Abstract
To study the distribution and localization of oil-soluble arteether in experimental mice, we injected C14-labelled arteether (20 μCi/kg body weight) intramuscularly and measured radioactivity in the blood, kidney, and liver. The labelled arteether distributed and localized more to the kidney (819,180.4 ± 34,134 dpm/cm3) than the liver (288,628.9 ± 54,954 dpm/cm3) 4 hours post-injection. The main localization of labelled arteether was in the kidney cortex rather than the medulla (p < 0.05). However, the distribution of radioactivity was homogeneous in the liver. The terminal half-life of labelled arteether in the blood was 1.8 hours. The blood: kidney: liver ratio was 1: 5: 2. These findings show that labelled arteether was distributed quickly and localized in the cytoplasmic cortex of the kidney and homogeneously in the liver.