Publication: Distribution of C14-labelled arteether in kidneys and livers of experimental mice after intramuscular injection
| dc.contributor.author | Cheeraratana Cheeramakara | en_US |
| dc.contributor.author | Vasant Khachonsaksumet | en_US |
| dc.contributor.author | Nopachai Suthisai | en_US |
| dc.contributor.author | Wanyarat Nakosiri | en_US |
| dc.contributor.author | Kriyaporn Songmuaeng | en_US |
| dc.contributor.author | Channarong Saenghirun | en_US |
| dc.contributor.author | Duangduen Phienpicharn | en_US |
| dc.contributor.author | Apichart Nontprasert | en_US |
| dc.contributor.other | Mahidol University | en_US |
| dc.date.accessioned | 2018-07-12T02:45:07Z | |
| dc.date.available | 2018-07-12T02:45:07Z | |
| dc.date.issued | 2008-03-01 | en_US |
| dc.description.abstract | To study the distribution and localization of oil-soluble arteether in experimental mice, we injected C14-labelled arteether (20 μCi/kg body weight) intramuscularly and measured radioactivity in the blood, kidney, and liver. The labelled arteether distributed and localized more to the kidney (819,180.4 ± 34,134 dpm/cm3) than the liver (288,628.9 ± 54,954 dpm/cm3) 4 hours post-injection. The main localization of labelled arteether was in the kidney cortex rather than the medulla (p < 0.05). However, the distribution of radioactivity was homogeneous in the liver. The terminal half-life of labelled arteether in the blood was 1.8 hours. The blood: kidney: liver ratio was 1: 5: 2. These findings show that labelled arteether was distributed quickly and localized in the cytoplasmic cortex of the kidney and homogeneously in the liver. | en_US |
| dc.identifier.citation | Southeast Asian Journal of Tropical Medicine and Public Health. Vol.39, No.2 (2008), 195-199 | en_US |
| dc.identifier.issn | 01251562 | en_US |
| dc.identifier.other | 2-s2.0-42349086514 | en_US |
| dc.identifier.uri | https://repository.li.mahidol.ac.th/handle/20.500.14594/19730 | |
| dc.rights | Mahidol University | en_US |
| dc.rights.holder | SCOPUS | en_US |
| dc.source.uri | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=42349086514&origin=inward | en_US |
| dc.subject | Medicine | en_US |
| dc.title | Distribution of C14-labelled arteether in kidneys and livers of experimental mice after intramuscular injection | en_US |
| dc.type | Article | en_US |
| dspace.entity.type | Publication | |
| mu.datasource.scopus | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=42349086514&origin=inward | en_US |