Publication: Fabrication of multiunit controlled-release phenylpropanolamine hydrochloride tablets
Issued Date
1998-01-01
Resource Type
ISSN
03639045
Other identifier(s)
2-s2.0-0031819923
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Mahidol University
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SCOPUS
Bibliographic Citation
Drug Development and Industrial Pharmacy. Vol.24, No.8 (1998), 793-796
Suggested Citation
Ampol Mitrevej, Nuttanan Sinchaipanid, Nuttawat Natpoolwat, Narakorn Naratikornrit Fabrication of multiunit controlled-release phenylpropanolamine hydrochloride tablets. Drug Development and Industrial Pharmacy. Vol.24, No.8 (1998), 793-796. doi:10.3109/03639049809082728 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/18347
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Title
Fabrication of multiunit controlled-release phenylpropanolamine hydrochloride tablets
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Abstract
Phenylpropanolamine hydrochloride (PPA) pellets were prepared in a fluidized-bed rotary granulator. Microcrystalline cellulose and distilled water were used as pelletization enhancer and binder, respectively. The pellets were coated with methacrylate ester copolymer (Eudragit(R) RS 100) solution containing a 1:1 ratio mixture of triethyl citrate and castor oil as plasticizers. The addition of approximately 30% microcrystalline cellulose and 2% croscarmellose sodium to the 50% coated pellets produced fast disintegrating tablets. Dissolution profiles of both pellets and their respective matrix tablets were comparable and conformed to the USP dissolution requirement for PPA extended-release capsules.