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Fabrication of multiunit controlled-release phenylpropanolamine hydrochloride tablets

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dc.contributor.authorAmpol Mitrevejen_US
dc.contributor.authorNuttanan Sinchaipaniden_US
dc.contributor.authorNuttawat Natpoolwaten_US
dc.contributor.authorNarakorn Naratikornriten_US
dc.contributor.otherMahidol Universityen_US
dc.date.accessioned2018-07-04T08:05:26Z
dc.date.available2018-07-04T08:05:26Z
dc.date.issued1998-01-01en_US
dc.description.abstractPhenylpropanolamine hydrochloride (PPA) pellets were prepared in a fluidized-bed rotary granulator. Microcrystalline cellulose and distilled water were used as pelletization enhancer and binder, respectively. The pellets were coated with methacrylate ester copolymer (Eudragit(R) RS 100) solution containing a 1:1 ratio mixture of triethyl citrate and castor oil as plasticizers. The addition of approximately 30% microcrystalline cellulose and 2% croscarmellose sodium to the 50% coated pellets produced fast disintegrating tablets. Dissolution profiles of both pellets and their respective matrix tablets were comparable and conformed to the USP dissolution requirement for PPA extended-release capsules.en_US
dc.identifier.citationDrug Development and Industrial Pharmacy. Vol.24, No.8 (1998), 793-796en_US
dc.identifier.doi10.3109/03639049809082728en_US
dc.identifier.issn03639045en_US
dc.identifier.other2-s2.0-0031819923en_US
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/20.500.14594/18347
dc.rightsMahidol Universityen_US
dc.rights.holderSCOPUSen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0031819923&origin=inwarden_US
dc.subjectChemistryen_US
dc.subjectPharmacology, Toxicology and Pharmaceuticsen_US
dc.titleFabrication of multiunit controlled-release phenylpropanolamine hydrochloride tabletsen_US
dc.typeArticleen_US
dspace.entity.typePublication
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0031819923&origin=inwarden_US

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