Publication: Pharmacokinetic interactions of artemether and pyrimethamine in healthy male Thais
Issued Date
1998-03-01
Resource Type
ISSN
01251562
Other identifier(s)
2-s2.0-0032014191
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Mahidol University
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SCOPUS
Bibliographic Citation
Southeast Asian Journal of Tropical Medicine and Public Health. Vol.29, No.1 (1998), 18-23
Suggested Citation
Peerapan Tan-ariya, Kesara Na-Bangchang, Ratawan Ubalee, Aurathai Thanavibul, Pongsri Thipawangkosol, Juntra Karbwang Pharmacokinetic interactions of artemether and pyrimethamine in healthy male Thais. Southeast Asian Journal of Tropical Medicine and Public Health. Vol.29, No.1 (1998), 18-23. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/18553
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Title
Pharmacokinetic interactions of artemether and pyrimethamine in healthy male Thais
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Abstract
The pharmacokinetics of a single oral dose of artemether (300 mg) and pyrimethamine (100 mg) given as each individual drug alone or as a drug combination (artemether 300 mg plus pyrimethamine 100 mg), were investigated in 8 healthy male Thai volunteers. Both artemether and pyrimethamine were rapidly absorbed after oral administration. Elimination of pyrimethamine was however, a relatively slow process compared with artemether, and thus resulted in a long terminal phase elimination half-life (50-106 hours). Pharmacokinetics of artemether and dihydroartemisinin following a single oral dose of artemether alone or in combination with pyrimethamine were similar. In contrast, coadministration of artemether resulted in significantly increased Cmax (medians of 818 vs 1,180 ng/ml) and contracted the apparent volume of distribution (medians of 3 vs 2.56 1/kg) of pyrimethamine.