Publication: New Fluorene Derivatives from Dendrobium gibsonii and Their α-Glucosidase Inhibitory Activity
Issued Date
2020-10-25
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ISSN
14203049
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2-s2.0-85094830587
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Mahidol University
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SCOPUS
Bibliographic Citation
Molecules (Basel, Switzerland). Vol.25, No.21 (2020)
Suggested Citation
May Thazin Thant, Nutputsorn Chatsumpun, Wanwimon Mekboonsonglarp, Boonchoo Sritularak, Kittisak Likhitwitayawuid New Fluorene Derivatives from Dendrobium gibsonii and Their α-Glucosidase Inhibitory Activity. Molecules (Basel, Switzerland). Vol.25, No.21 (2020). doi:10.3390/molecules25214931 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/59866
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Title
New Fluorene Derivatives from Dendrobium gibsonii and Their α-Glucosidase Inhibitory Activity
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Abstract
Two new compounds, dihydrodengibsinin (1) and dendrogibsol (2), were isolated from the whole plant of Dendrobium gibsonii, together with seven known compounds (3-9). The structures of the new compounds were elucidated by their spectroscopic data. All these isolates were evaluated for their α-glucosidase inhibitory activities. Dendrogibsol (2) and lusianthridin (7) showed strong α-glucosidase inhibitory activity when compared with acarbose. An enzyme kinetic study revealed that dendrogibsol (2) is a noncompetitive inhibitor of α-glucosidase.