Publication: Induction of human cholesterol 7α-hydroxylase in HepG2 cells by 2,4,6-trihydroxyacetophenone
| dc.contributor.author | Juree Charoenteeraboon | en_US |
| dc.contributor.author | Kasem Nithipatikom | en_US |
| dc.contributor.author | William B. Campbell | en_US |
| dc.contributor.author | Pawinee Piyachaturawat | en_US |
| dc.contributor.author | Prapon Wilairat | en_US |
| dc.contributor.author | Pornpimol Rongnoparut | en_US |
| dc.contributor.other | Mahidol University | en_US |
| dc.contributor.other | Medical College of Wisconsin | en_US |
| dc.date.accessioned | 2018-06-21T08:32:54Z | |
| dc.date.available | 2018-06-21T08:32:54Z | |
| dc.date.issued | 2005-05-16 | en_US |
| dc.description.abstract | In animal the plasma cholesterol-lowering activity of 2,4,6- trihydroxyacetophenone (THA) is due to enhanced cholesterol 7α-hydroxylase (CYP7A1) activity. We have examined the effect of THA on CYP7A1 activity and mRNA level in HepG2 cells. THA stimulated CYP7A1 activity in a concentration- and time-dependent manner. After exposure for 24 h, 1 μM THA induced CYP7A1 activity 160 ± 8% and mRNA level 166 ± 21% (mean ± S.E.M.) of control. Moreover THA antagonized the inhibitory regulation of chenodeoxycholic acid on CYP7A1 mRNA expression. These results indicated that THA increases CYP7A1 activity in human HepG2 cells by stimulating mRNA transcription. © 2005 Elsevier B.V. All rights reserved. | en_US |
| dc.identifier.citation | European Journal of Pharmacology. Vol.515, No.1-3 (2005), 43-46 | en_US |
| dc.identifier.doi | 10.1016/j.ejphar.2005.03.039 | en_US |
| dc.identifier.issn | 00142999 | en_US |
| dc.identifier.other | 2-s2.0-20344362658 | en_US |
| dc.identifier.uri | https://repository.li.mahidol.ac.th/handle/20.500.14594/17146 | |
| dc.rights | Mahidol University | en_US |
| dc.rights.holder | SCOPUS | en_US |
| dc.source.uri | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=20344362658&origin=inward | en_US |
| dc.subject | Neuroscience | en_US |
| dc.subject | Pharmacology, Toxicology and Pharmaceutics | en_US |
| dc.title | Induction of human cholesterol 7α-hydroxylase in HepG2 cells by 2,4,6-trihydroxyacetophenone | en_US |
| dc.type | Article | en_US |
| dspace.entity.type | Publication | |
| mu.datasource.scopus | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=20344362658&origin=inward | en_US |